AIM: To analyze the value of computed tomography (CT) volume measurements for evaluation of the survival rate of unresectable hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). METHODS: One hundred and sixty-six unresectable HCC patients after TACE were involved in this retrospective study. Hepatic CT scan was performed for all patients before and 4 wk to 2 mo after TACE to define the morphologic features of HCC including its largest diameter, volume, product of the greatest axial dimension, tumor to liver volume ratio (TTLVR), and tumor shrinkage ratio. Clinical variables used in the study included gender, age, pattern of tumor growth, number of lesions, Child-Pugh classification of liver function, repeated TACE times, pre- or post-treatment alpha-fetoprotein (AFP) level, portal vein cancerous thrombus, tumor metastasis, degree of lipiodol retention within the tumor, and percutaneous ethanol injection. The correlation between survival time and clinical variables of patients or lesions was analyzed by combining morphologic features with the corresponding clinical and general data as input. A Cox proportional hazard model was used to analyze prognostic factors. The Kaplan-Meier method was used to calculate the cumulative survival time. Influence of the parameters on prognosis was analyzed by the log-rank test. RESULTS: The overall 6, 12, 24, 36 and 60 mo cumulative survival rates were 78.92%, 49.85%, 23.82%, 15.60% and 8.92%, respectively. The median survival time was 12 mo. Univariate and multivariate analysis showed that only 4 parameters were the independent prognostic factors including TTLVR (chi(2) = 14.328, P < 0.001), portal vein cancerous thrombus (chi(2) = 5.643, P = 0.018), repeated TACE times (chi(2) = 8.746, P = 0.003), and post-treatment serum AFP level (chi(2) = 5.416, P = 0.020). When the TTLVR value was less than 70%, the survival time was inversely correlated with the TTLVR value. CONCLUSION: CT volume measurement technique can predict the prognosis of unresectable HCC patients after TACE.
AIM: To analyze the value of computed tomography (CT) volume measurements for evaluation of the survival rate of unresectable hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). METHODS: One hundred and sixty-six unresectable HCCpatients after TACE were involved in this retrospective study. Hepatic CT scan was performed for all patients before and 4 wk to 2 mo after TACE to define the morphologic features of HCC including its largest diameter, volume, product of the greatest axial dimension, tumor to liver volume ratio (TTLVR), and tumor shrinkage ratio. Clinical variables used in the study included gender, age, pattern of tumor growth, number of lesions, Child-Pugh classification of liver function, repeated TACE times, pre- or post-treatment alpha-fetoprotein (AFP) level, portal vein cancerous thrombus, tumor metastasis, degree of lipiodol retention within the tumor, and percutaneous ethanol injection. The correlation between survival time and clinical variables of patients or lesions was analyzed by combining morphologic features with the corresponding clinical and general data as input. A Cox proportional hazard model was used to analyze prognostic factors. The Kaplan-Meier method was used to calculate the cumulative survival time. Influence of the parameters on prognosis was analyzed by the log-rank test. RESULTS: The overall 6, 12, 24, 36 and 60 mo cumulative survival rates were 78.92%, 49.85%, 23.82%, 15.60% and 8.92%, respectively. The median survival time was 12 mo. Univariate and multivariate analysis showed that only 4 parameters were the independent prognostic factors including TTLVR (chi(2) = 14.328, P < 0.001), portal vein cancerous thrombus (chi(2) = 5.643, P = 0.018), repeated TACE times (chi(2) = 8.746, P = 0.003), and post-treatment serum AFP level (chi(2) = 5.416, P = 0.020). When the TTLVR value was less than 70%, the survival time was inversely correlated with the TTLVR value. CONCLUSION: CT volume measurement technique can predict the prognosis of unresectable HCCpatients after TACE.
Authors: Srinivasa R Prasad; Kartik S Jhaveri; Sanjay Saini; Peter F Hahn; Elkan F Halpern; James E Sumner Journal: Radiology Date: 2002-11 Impact factor: 11.105
Authors: W Patrick Soutter; Joseph Hanoch; Tom D'Arcy; Roberto Dina; G Angus McIndoe; Nandita M DeSouza Journal: BJOG Date: 2004-07 Impact factor: 6.531
Authors: Francesco Vasuri; Deborah Malvi; Francesca Rosini; Pamela Baldin; Michelangelo Fiorentino; Alexandro Paccapelo; Giorgio Ercolani; Antonio Daniele Pinna; Rita Golfieri; Antonio Maria Morselli-Labate; Walter Franco Grigioni; Antonia D'Errico-Grigioni Journal: World J Gastroenterol Date: 2014-10-07 Impact factor: 5.742
Authors: M W Huellner; T P Hennedige; R Winterhalder; T Zander; S K Venkatesh; W P Yong; R A Soo; B Seifert; T C Treumann; K Strobel; P Veit-Haibach Journal: Cancer Imaging Date: 2012-05-21 Impact factor: 3.909
Authors: Francesco Fiorica; Carlo Greco; Sergio Boccia; Sergio Sartori; Antonio Stefanelli; Francesco Cartei; Stefano Ursino Journal: Case Reports Hepatol Date: 2013-03-10
Authors: Argyro Mazioti; Nikolaos K Gatselis; Christos Rountas; Kalliopi Zachou; Dimitrios K Filippiadis; Kostantinos Tepetes; George K Koukoulis; Ioannis Fezoulidis; George N Dalekos Journal: Hepat Mon Date: 2013-08-12 Impact factor: 0.660
Authors: Ting Duan; Hanyu Jiang; Chunchao Xia; Jie Chen; Likunn Cao; Zheng Ye; Yi Wei; Bin Song; Jeong Min Lee Journal: Front Med (Lausanne) Date: 2020-05-28