Literature DB >> 20415651

Expression and function of microRNAs in heart disease.

Sadakatsu Ikeda1, William T Pu.   

Abstract

MicroRNAs (miRNAs) are powerful, recently recognized regulators of gene expression. miRNAs modulate virtually all aspects of cardiac biology, from cardiac specification and development to cardiomyocyte survival and hypertrophy. Expression profiling of experimental and human heart disease has shown that miRNA expression is altered in heart disease, and miRNA expression signatures may be useful biomarkers for heart disease diagnosis and prognosis. Mechanistic studies have revealed how miRNAs contribute to heart disease pathogenesis. Here we review the expression and function of miRNAs in heart disease.

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Year:  2010        PMID： 20415651     DOI： 10.2174/138945010791591304

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  27 in total

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Review 4.  Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation.

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Review 6.  MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine.

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8.  Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

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Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-10       Impact factor: 11.205

9.  Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function.

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10.  Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system.

Authors:  Jacqueline R Kemp; Hamiyet Unal; Russell Desnoyer; Hong Yue; Anushree Bhatnagar; Sadashiva S Karnik
Journal:  J Mol Cell Cardiol       Date:  2014-06-27       Impact factor: 5.000
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