Literature DB >> 20410014

Cellular and molecular basis for the regulation of inflammation by TGF-beta.

Akihiko Yoshimura1, Yu Wakabayashi, Tomoaki Mori.   

Abstract

Transforming growth factor-beta (TGF-beta) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-beta in inflammatory responses. For example, TGF-beta induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-beta inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-beta; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-gamma suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-beta and other cytokine signaling is important in establishing the balance of immunity and tolerance.

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Year:  2010        PMID： 20410014      PMCID： PMC2912031          DOI： 10.1093/jb/mvq043

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  123 in total

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Journal:  J Immunol       Date:  2010-06-14       Impact factor: 5.422

Review 4.  TGF-beta1 regulation of dendritic cells.

Authors:  H Strobl; W Knapp
Journal:  Microbes Infect       Date:  1999-12       Impact factor: 2.700

5.  Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.

Authors:  F Werner; M K Jain; M W Feinberg; N E Sibinga; A Pellacani; P Wiesel; M T Chin; J N Topper; M A Perrella; M E Lee
Journal:  J Biol Chem       Date:  2000-11-24       Impact factor: 5.157

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Authors:  L Gorelik; R A Flavell
Journal:  Immunity       Date:  2000-02       Impact factor: 31.745

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Authors:  V L Heath; E E Murphy; C Crain; M G Tomlinson; A O'Garra
Journal:  Eur J Immunol       Date:  2000-09       Impact factor: 5.532

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Authors:  B R Lúdvíksson; D Seegers; A S Resnick; W Strober
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10.  Microbial lipopeptides induce the production of IL-17 in Th cells.

Authors:  C Infante-Duarte; H F Horton; M C Byrne; T Kamradt
Journal:  J Immunol       Date:  2000-12-01       Impact factor: 5.422
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  133 in total

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Review 5.  TGF-β signaling in C. elegans.

Authors:  Tina L Gumienny; Cathy Savage-Dunn
Journal:  WormBook       Date:  2013-07-10

6.  Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.

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Review 7.  The role of cytokines in breast cancer development and progression.

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8.  Immunization against TGF-β1 reduces collagen deposition but increases sustained inflammation in a murine asthma model.

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9.  TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5.

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10.  Association of heme oxygenase 1 with the restoration of liver function after damage in murine malaria by Plasmodium yoelii.

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