Literature DB >> 11045997

Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

L Gorelik1, P E Fields, R A Flavell.   

Abstract

TGF-beta is an important immunomodulatory cytokine that can inhibit differentiation of effector T cells. In this report, we address the molecular mechanisms through which TGF-beta inhibits differentiation of CD4(+) cells into Th type 2 cells. We demonstrate that TGF-beta inhibits GATA-3 expression in developing Th cells. We also show that inhibition of GATA-3 expression by TGF-beta is a major mechanism of inhibition of Th2 differentiation by TGF-beta as ectopic expression of GATA-3 in developing T cells overcomes the ability of TGF-beta to inhibit Th2 differentiation. TGF-beta likely inhibits GATA-3 expression at the transcriptional level and does so without interfering with IL-4 signaling.

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Year:  2000        PMID： 11045997     DOI： 10.4049/jimmunol.165.9.4773

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  129 in total

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Review 8.  Allergen immunotherapy for allergic respiratory diseases.

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9.  Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis.

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Journal:  Brain Behav Immun       Date:  2014-12-10       Impact factor: 7.217

Review 10.  TGF-β: guardian of T cell function.

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Journal:  J Immunol       Date:  2013-10-15       Impact factor: 5.422
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