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Literature DB >> 20407668

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models.

Tom A Barr¹, Martin Krembuszewski, Manish Gupta, David Gray, Juan C Mareque-Rivas.

Abstract

We attached the pathogen associated molecular pattern Kdo(2)-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo.

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 20407668 PMCID： PMC3745604 DOI： 10.1039/c002066d

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

37 in total

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5. Location, location, location: identifying the neighborhoods of LPS signaling.

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6. Monovalent, reduced-size quantum dots for imaging receptors on living cells.

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7. Ni-nitrilotriacetic acid-modified quantum dots as a site-specific labeling agent of histidine-tagged proteins in live cells.

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2. Comparative conventional- and quantum dot-labeling strategies for LPS binding site detection in Arabidopsis thaliana mesophyll protoplasts.

Authors: Londiwe S Mgcina; Ian A Dubery; Lizelle A Piater
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2 in total

Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models.

Review 1. Creating new fluorescent probes for cell biology.

Review 2. Interleukin-6 and its receptor: a paradigm for cytokines.

3. Cooperation between artificial receptors and supramolecular hydrogels for sensing and discriminating phosphate derivatives.

4. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.

5. Location, location, location: identifying the neighborhoods of LPS signaling.

6. Monovalent, reduced-size quantum dots for imaging receptors on living cells.

7. Ni-nitrilotriacetic acid-modified quantum dots as a site-specific labeling agent of histidine-tagged proteins in live cells.

8. Recognition and plasma clearance of endotoxin by scavenger receptors.

9. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

10. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction.

1. Expression and significance of quantum dots in RAW 264.7 macrophages.

2. Comparative conventional- and quantum dot-labeling strategies for LPS binding site detection in Arabidopsis thaliana mesophyll protoplasts.