BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7)). METHODS: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. RESULTS: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P=7.79x10(-11); ORHET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P=1.60x10(-4) for aggressive cancer, n=4,597; P=3.25x10(-8) for nonaggressive cancer, n=4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P=0.587), body stature (rs849141, tagged by rs849136; P=0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P=0.657). CONCLUSION: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. IMPACT: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa. Copyright (c) 2010 AACR
BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7)). METHODS: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. RESULTS: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P=7.79x10(-11); ORHET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P=1.60x10(-4) for aggressive cancer, n=4,597; P=3.25x10(-8) for nonaggressive cancer, n=4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P=0.587), body stature (rs849141, tagged by rs849136; P=0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P=0.657). CONCLUSION:rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. IMPACT: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa. Copyright (c) 2010 AACR
Authors: J I Koontz; A L Soreng; M Nucci; F C Kuo; P Pauwels; H van Den Berghe; P Dal Cin; J A Fletcher; J Sklar Journal: Proc Natl Acad Sci U S A Date: 2001-05-22 Impact factor: 11.205
Authors: Meredith Yeager; Nick Orr; Richard B Hayes; Kevin B Jacobs; Peter Kraft; Sholom Wacholder; Mark J Minichiello; Paul Fearnhead; Kai Yu; Nilanjan Chatterjee; Zhaoming Wang; Robert Welch; Brian J Staats; Eugenia E Calle; Heather Spencer Feigelson; Michael J Thun; Carmen Rodriguez; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Edward Giovannucci; Walter C Willett; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; Edward P Gelmann; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert Hoover; David J Hunter; Stephen J Chanock; Gilles Thomas Journal: Nat Genet Date: 2007-04-01 Impact factor: 38.330
Authors: L N Kolonel; B E Henderson; J H Hankin; A M Nomura; L R Wilkens; M C Pike; D O Stram; K R Monroe; M E Earle; F S Nagamine Journal: Am J Epidemiol Date: 2000-02-15 Impact factor: 4.897
Authors: E Riboli; K J Hunt; N Slimani; P Ferrari; T Norat; M Fahey; U R Charrondière; B Hémon; C Casagrande; J Vignat; K Overvad; A Tjønneland; F Clavel-Chapelon; A Thiébaut; J Wahrendorf; H Boeing; D Trichopoulos; A Trichopoulou; P Vineis; D Palli; H B Bueno-De-Mesquita; P H M Peeters; E Lund; D Engeset; C A González; A Barricarte; G Berglund; G Hallmans; N E Day; T J Key; R Kaaks; R Saracci Journal: Public Health Nutr Date: 2002-12 Impact factor: 4.022
Authors: Wendy Winckler; Michael N Weedon; Robert R Graham; Steven A McCarroll; Shaun Purcell; Peter Almgren; Tiinamaija Tuomi; Daniel Gaudet; Kristina Bengtsson Boström; Mark Walker; Graham Hitman; Andrew T Hattersley; Mark I McCarthy; Kristin G Ardlie; Joel N Hirschhorn; Mark J Daly; Timothy M Frayling; Leif Groop; David Altshuler Journal: Diabetes Date: 2007-03 Impact factor: 9.461
Authors: Fredrick R Schumacher; Sonja I Berndt; Afshan Siddiq; Kevin B Jacobs; Zhaoming Wang; Sara Lindstrom; Victoria L Stevens; Constance Chen; Alison M Mondul; Ruth C Travis; Daniel O Stram; Rosalind A Eeles; Douglas F Easton; Graham Giles; John L Hopper; David E Neal; Freddie C Hamdy; Jenny L Donovan; Kenneth Muir; Ali Amin Al Olama; Zsofia Kote-Jarai; Michelle Guy; Gianluca Severi; Henrik Grönberg; William B Isaacs; Robert Karlsson; Fredrik Wiklund; Jianfeng Xu; Naomi E Allen; Gerald L Andriole; Aurelio Barricarte; Heiner Boeing; H Bas Bueno-de-Mesquita; E David Crawford; W Ryan Diver; Carlos A Gonzalez; J Michael Gaziano; Edward L Giovannucci; Mattias Johansson; Loic Le Marchand; Jing Ma; Sabina Sieri; Pär Stattin; Meir J Stampfer; Anne Tjonneland; Paolo Vineis; Jarmo Virtamo; Ulla Vogel; Stephanie J Weinstein; Meredith Yeager; Michael J Thun; Laurence N Kolonel; Brian E Henderson; Demetrius Albanes; Richard B Hayes; Heather Spencer Feigelson; Elio Riboli; David J Hunter; Stephen J Chanock; Christopher A Haiman; Peter Kraft Journal: Hum Mol Genet Date: 2011-07-08 Impact factor: 6.150
Authors: Mitchell J Machiela; Constance Chen; Liming Liang; W Ryan Diver; Victoria L Stevens; Konstantinos K Tsilidis; Christopher A Haiman; Stephen J Chanock; David J Hunter; Peter Kraft Journal: Prostate Date: 2012-12-19 Impact factor: 4.104
Authors: Christine Neslund-Dudas; Albert M Levin; Jennifer L Beebe-Dimmer; Cathryn H Bock; Nora L Nock; Andrew Rundle; Michelle Jankowski; Richard Krajenta; Q Ping Dou; Bharati Mitra; Deliang Tang; Timothy R Rebbeck; Benjamin A Rybicki Journal: Cancer Causes Control Date: 2014-05-07 Impact factor: 2.506
Authors: Mitchell J Machiela; Sara Lindström; Naomi E Allen; Christopher A Haiman; Demetrius Albanes; Aurelio Barricarte; Sonja I Berndt; H Bas Bueno-de-Mesquita; Stephen Chanock; J Michael Gaziano; Susan M Gapstur; Edward Giovannucci; Brian E Henderson; Eric J Jacobs; Laurence N Kolonel; Vittorio Krogh; Jing Ma; Meir J Stampfer; Victoria L Stevens; Daniel O Stram; Anne Tjønneland; Ruth Travis; Walter C Willett; David J Hunter; Loic Le Marchand; Peter Kraft Journal: Am J Epidemiol Date: 2012-11-28 Impact factor: 4.897
Authors: Bao-Li Chang; Elaine Spangler; Stephen Gallagher; Christopher A Haiman; Brian Henderson; William Isaacs; Marnita L Benford; LaCreis R Kidd; Kathleen Cooney; Sara Strom; Sue Ann Ingles; Mariana C Stern; Roman Corral; Amit D Joshi; Jianfeng Xu; Veda N Giri; Benjamin Rybicki; Christine Neslund-Dudas; Adam S Kibel; Ian M Thompson; Robin J Leach; Elaine A Ostrander; Janet L Stanford; John Witte; Graham Casey; Rosalind Eeles; Ann W Hsing; Stephen Chanock; Jennifer J Hu; Esther M John; Jong Park; Klara Stefflova; Charnita Zeigler-Johnson; Timothy R Rebbeck Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-11-11 Impact factor: 4.254
Authors: J Vijai; T Kirchhoff; D Gallagher; N Hamel; S Guha; A Darvasi; T Lencz; W D Foulkes; K Offit; R J Klein Journal: Br J Cancer Date: 2011-08-09 Impact factor: 7.640
Authors: Pawel Gaj; Natalia Maryan; Ewa E Hennig; Joanna K Ledwon; Agnieszka Paziewska; Aneta Majewska; Jakub Karczmarski; Monika Nesteruk; Jan Wolski; Artur A Antoniewicz; Krzysztof Przytulski; Andrzej Rutkowski; Alexander Teumer; Georg Homuth; Teresa Starzyńska; Jaroslaw Regula; Jerzy Ostrowski Journal: PLoS One Date: 2012-04-19 Impact factor: 3.240