Literature DB >> 17681401

Maxadilan, a PAC1 receptor agonist from sand flies.

Ethan A Lerner1, Aurel O Iuga, Vemuri B Reddy.   

Abstract

In 1991, a potent 61 amino acid vasodilator peptide, named maxadilan, was isolated from the salivary glands of the sand fly. Subsequently, it was shown that this peptide specifically and potently activated the mammalian PAC1 receptor, one of the three receptors for PACAP. These studies and the link between maxadilan and leishmaniasis are discussed.

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Year:  2007        PMID： 17681401      PMCID： PMC2074892          DOI： 10.1016/j.peptides.2007.06.021

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  20 in total

1.  Antigenic diversity in maxadilan, a salivary protein from the sand fly vector of American visceral leishmaniasis.

Authors:  Rania S Milleron; John-Paul Mutebi; Sonia Valle; Alberto Montoya; Huaizhi Yin; Lynn Soong; Gregory C Lanzaro
Journal:  Am J Trop Med Hyg       Date:  2004-03       Impact factor: 2.345

2.  Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.

Authors:  E A Lerner; J M Ribeiro; R J Nelson; M R Lerner
Journal:  J Biol Chem       Date:  1991-06-15       Impact factor: 5.157

3.  Functional analysis of recombinant mutants of maxadilan with a PAC1 receptor-expressing melanophore cell line.

Authors:  Vemuri B Reddy; Aurel O Iuga; Kounga Kounga; Ethan A Lerner
Journal:  J Biol Chem       Date:  2006-03-28       Impact factor: 5.157

4.  Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum.

Authors:  William R Gower; John R Dietz; Robert W McCuen; Peter J Fabri; Ethan A Lerner; Mitchell L Schubert
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2003-01       Impact factor: 4.052

5.  Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity.

Authors:  R G Titus; J M Ribeiro
Journal:  Science       Date:  1988-03-11       Impact factor: 47.728

6.  Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice.

Authors:  C M Theodos; J M Ribeiro; R G Titus
Journal:  Infect Immun       Date:  1991-05       Impact factor: 3.441

7.  Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection.

Authors:  R V Morris; C B Shoemaker; J R David; G C Lanzaro; R G Titus
Journal:  J Immunol       Date:  2001-11-01       Impact factor: 5.422

8.  Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis.

Authors:  A Warburg; E Saraiva; G C Lanzaro; R G Titus; F Neva
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1994-07-29       Impact factor: 6.237

9.  Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptide.

Authors:  E A Lerner; C B Shoemaker
Journal:  J Biol Chem       Date:  1992-01-15       Impact factor: 5.157

10.  PACAP promotes neural stem cell proliferation in adult mouse brain.

Authors:  Alex Mercer; Harriet Rönnholm; Johan Holmberg; Hanna Lundh; Jessica Heidrich; Olof Zachrisson; Amina Ossoinak; Jonas Frisén; Cesare Patrone
Journal:  J Neurosci Res       Date:  2004-04-15       Impact factor: 4.164
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  21 in total

1.  Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.

Authors:  Erik Svensjö; Elvira M Saraiva; Rafael Silveira Amendola; Christina Barja-Fidalgo; Marcelo T Bozza; Ethan A Lerner; Mauro M Teixeira; Julio Scharfstein
Journal:  Microvasc Res       Date:  2011-10-19       Impact factor: 3.514

2.  Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors are present and biochemically active in the central nervous system of the pond snail Lymnaea stagnalis.

Authors:  Zsolt Pirger; Zita Laszlo; Laszlo Hiripi; Laszlo Hernadi; Gabor Toth; Andrea Lubics; Dora Reglodi; Gyorgy Kemenes; Laszlo Mark
Journal:  J Mol Neurosci       Date:  2010-04-16       Impact factor: 3.444

3.  Activation of PAC(1) and VPAC receptor subtypes elicits differential physiological responses from sympathetic preganglionic neurons in the anaesthetized rat.

Authors:  Melissa A Inglott; Ethan A Lerner; Paul M Pilowsky; Melissa M J Farnham
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

4.  PACAP protects against TNFα-induced cell death in olfactory epithelium and olfactory placodal cell lines.

Authors:  Shami Kanekar; Mahendra Gandham; Mary T Lucero
Journal:  Mol Cell Neurosci       Date:  2010-07-21       Impact factor: 4.314

Review 5.  VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies.

Authors:  Terry W Moody; Tetsuhide Ito; Nuramy Osefo; Robert T Jensen
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2011-02       Impact factor: 3.243

6.  The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration.

Authors:  A Vaczy; D Reglodi; T Somoskeoy; K Kovacs; E Lokos; E Szabo; A Tamas; T Atlasz
Journal:  J Mol Neurosci       Date:  2016-08-26       Impact factor: 3.444

7.  Differential activation of guinea pig intrinsic cardiac neurons by the PAC1 agonists maxadilan and pituitary adenylate cyclase-activating polypeptide 27 (PACAP27).

Authors:  Donald B Hoover; John D Tompkins; Rodney L Parsons
Journal:  J Pharmacol Exp Ther       Date:  2009-07-14       Impact factor: 4.030

8.  The serendipitous origin of chordate secretin peptide family members.

Authors:  João C R Cardoso; Florbela A Vieira; Ana S Gomes; Deborah M Power
Journal:  BMC Evol Biol       Date:  2010-05-06       Impact factor: 3.260

9.  PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Authors:  Cornelia Ringer; Luisa-Sybille Büning; Martin K H Schäfer; Lee E Eiden; Eberhard Weihe; Burkhard Schütz
Journal:  Neurobiol Dis       Date:  2013-03-04       Impact factor: 5.996

Review 10.  Eosinophils and mast cells in leishmaniasis.

Authors:  Nilda E Rodríguez; Mary E Wilson
Journal:  Immunol Res       Date:  2014-08       Impact factor: 2.829
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