Renato C Monteiro1. 1. Inserm U699, Paris, France. renato.monteiro@inserm.fr
Abstract
MATERIALS AND METHODS: Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through FcalphaRI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system. RESULTS: Triggering of FcalphaRI-mediated inhibitory function by Fab anti-FcalphaRI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis. CONCLUSION: The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.
MATERIALS AND METHODS: Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through FcalphaRI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system. RESULTS: Triggering of FcalphaRI-mediated inhibitory function by Fab anti-FcalphaRI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis. CONCLUSION: The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.
Authors: Whitney S Livingston; Jessica M Gill; Martin R Cota; Anlys Olivera; Jessica L O'Keefe; Christiana Martin; Lawrence L Latour Journal: J Neurotrauma Date: 2016-08-30 Impact factor: 5.269
Authors: Gülşen Özkaya Şahin; Fredrik Månsson; Angelica A Palm; Elzbieta Vincic; Zacarias da Silva; Patrik Medstrand; Hans Norrgren; Eva Maria Fenyö; Marianne Jansson Journal: AIDS Res Hum Retroviruses Date: 2012-11-21 Impact factor: 2.205
Authors: N Nair; E W Newell; C Vollmers; S R Quake; J M Morton; M M Davis; X S He; H B Greenberg Journal: Mucosal Immunol Date: 2015-04-22 Impact factor: 7.313