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Literature DB >> 21691145

Immunoglobulin A: A next generation of therapeutic antibodies?

Jantine E Bakema¹, Marjolein van Egmond.

Abstract

Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non-, and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.

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Year: 2011 PMID： 21691145 PMCID： PMC3218532 DOI： 10.4161/mabs.3.4.16092

Source DB: PubMed Journal: MAbs ISSN： 1942-0862 Impact factor: 5.857

143 in total

1. Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89.

Authors: R J Pleass; J I Dunlop; C M Anderson; J M Woof
Journal: J Biol Chem Date: 1999-08-13 Impact factor: 5.157

2. Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM.

Authors: Benoit Pasquier; Pierre Launay; Yutaka Kanamaru; Ivan C Moura; Séverine Pfirsch; Claude Ruffié; Dominique Hénin; Marc Benhamou; Marina Pretolani; Ulrich Blank; Renato C Monteiro
Journal: Immunity Date: 2005-01 Impact factor: 31.745

3. The human Fc receptor for IgA (Fc alpha RI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis.

Authors: M van Egmond; A J Hanneke van Vuuren; J G van de Winkel
Journal: Immunol Lett Date: 1999-05-03 Impact factor: 3.685

4. Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors.

Authors: Marielle A Otten; Esther Rudolph; Michael Dechant; Cornelis W Tuk; Rogier M Reijmers; Robert H J Beelen; Jan G J van de Winkel; Marjolein van Egmond
Journal: J Immunol Date: 2005-05-01 Impact factor: 5.422

5. A novel polymorphism in the cytoplasmic region of the human immunoglobulin A Fc receptor gene.

Authors: M Jasek; M Mańczak; A Sawaryn; A Obojski; A Wiśniewski; W Łuszczek; P Kuśnierczyk
Journal: Eur J Immunogenet Date: 2004-04

6. Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry.

Authors: Edward Tarelli; Alice C Smith; Bruce M Hendry; Stephen J Challacombe; Shideh Pouria
Journal: Carbohydr Res Date: 2004-09-13 Impact factor: 2.104

7. Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with FcalphaRI, surface expression, and function.

Authors: Bruce D Wines; Halina M Trist; Renato C Monteiro; Cees Van Kooten; P Mark Hogarth
Journal: J Biol Chem Date: 2004-04-19 Impact factor: 5.157

8. Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein.

Authors: Paul J Tacken; Kevan L Hartshorn; Mitchell R White; Cees van Kooten; Jan G J van de Winkel; Ken B M Reid; Joseph J Batenburg
Journal: J Immunol Date: 2004-04-15 Impact factor: 5.422

Review 9. Human antibody-Fc receptor interactions illuminated by crystal structures.

Authors: Jenny M Woof; Dennis R Burton
Journal: Nat Rev Immunol Date: 2004-02 Impact factor: 53.106

10. Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaques.

Authors: H Craig Morton; Richard J Pleass; Anne K Storset; Per Brandtzaeg; Jenny M Woof
Journal: Immunology Date: 2005-05 Impact factor: 7.397

27 in total

1. IgA attenuates anaphylaxis and subsequent immune responses in mice: possible application of IgA to vaccines.

Authors: Kouya Yamaki; Takayuki Nakashima; Kenji Miyatake; Yuki Ishibashi; Ayaka Ito; Ayu Kuranishi; Akihito Taguchi; Ayumi Morioka; Midori Yamamoto; Shin Yoshino
Journal: Immunol Res Date: 2014-01 Impact factor: 2.829

Review 2. Using glyco-engineering to produce therapeutic proteins.

Authors: Martina Dicker; Richard Strasser
Journal: Expert Opin Biol Ther Date: 2015-07-14 Impact factor: 4.388

3. IgA Fc-folate conjugate activates and recruits neutrophils to directly target triple-negative breast cancer cells.

Authors: Eric D Frontera; Rafa M Khansa; Dana L Schalk; Lauren E Leakan; Tracey J Guerin-Edbauer; Manohar Ratnam; David H Gorski; Cecilia L Speyer
Journal: Breast Cancer Res Treat Date: 2018-08-28 Impact factor: 4.872

4. The Development and Inmmunochemical Properties of the Dimer of Immunoglobulin A Specific to the Influenza Virus A Hemagglutinin.

Authors: T K Aliev; I G Dement'eva; V A Toporova; V V Argentova; L P Pozdnyakova; M N Bokov; D A Dolgikh; P G Sveshnikov; M P Kirpichnikov
Journal: Dokl Biochem Biophys Date: 2018-03-14 Impact factor: 0.788