Literature DB >> 2040432

A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model.

R Sloane1, J C de Azavedo, J P Arbuthnott, P J Hartigan, B Kreiswirth, R Novick, T J Foster.   

Abstract

The gene coding for toxic shock syndrome toxin-1 in S. aureus was inactivated by allelic replacement in two TSS-associated strains. One mutant derived from FRI1169 (a non-enterotoxigenic strain) lacked virulence in the rabbit uterine chamber infection model. This suggests that TSST-1 is the only determinant produced by this strain that can induce the symptoms of shock in rabbits. A novel method for allelic replacement involving transduction of plasmid integrants is described.

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Year:  1991        PMID： 2040432     DOI： 10.1016/0378-1097(91)90164-6

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  10 in total

1.  Global repression of exotoxin synthesis by staphylococcal superantigens.

Authors:  Nikola Vojtov; Hope F Ross; Richard P Novick
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-10       Impact factor: 11.205

2.  Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer.

Authors:  Elisa Maiques; Carles Ubeda; María Angeles Tormo; María Desamparados Ferrer; Iñigo Lasa; Richard P Novick; José R Penadés
Journal:  J Bacteriol       Date:  2007-06-01       Impact factor: 3.490

3.  Transducing particles of Staphylococcus aureus pathogenicity island SaPI1 are comprised of helper phage-encoded proteins.

Authors:  Sandra M Tallent; Timothy B Langston; Richard G Moran; Gail E Christie
Journal:  J Bacteriol       Date:  2007-08-10       Impact factor: 3.490

4.  Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.

Authors:  Jason Yamaki; Timothy Synold; Annie Wong-Beringer
Journal:  Antimicrob Agents Chemother       Date:  2011-06-13       Impact factor: 5.191

5.  The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.

Authors:  Lawrence Y Lee; Yuko J Miyamoto; Bradley W McIntyre; Magnus Höök; Kirk W McCrea; Damien McDevitt; Eric L Brown
Journal:  J Clin Invest       Date:  2002-11       Impact factor: 14.808

6.  Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens.

Authors:  J R Fitzgerald; S R Monday; T J Foster; G A Bohach; P J Hartigan; W J Meaney; C J Smyth
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

7.  Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor.

Authors:  D McDevitt; P Vaudaux; T J Foster
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

8.  Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates.

Authors:  James Collins; Angus Buckling; Ruth C Massey
Journal:  J Clin Microbiol       Date:  2008-04-16       Impact factor: 5.948

9.  Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation.

Authors:  Caitriona M Guinane; Nouri L Ben Zakour; Maria A Tormo-Mas; Lucy A Weinert; Bethan V Lowder; Robyn A Cartwright; Davida S Smyth; Cyril J Smyth; Jodi A Lindsay; Katherine A Gould; Adam Witney; Jason Hinds; Jonathan P Bollback; Andrew Rambaut; José R Penadés; J Ross Fitzgerald
Journal:  Genome Biol Evol       Date:  2010-07-12       Impact factor: 3.416

10.  Agr-mediated dispersal of Staphylococcus aureus biofilms.

Authors:  Blaise R Boles; Alexander R Horswill
Journal:  PLoS Pathog       Date:  2008-04-25       Impact factor: 6.823
  10 in total

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