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Literature DB >> 21670179

Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.

Jason Yamaki¹, Timothy Synold, Annie Wong-Beringer.

Abstract

Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.

Entities: Chemical Species

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Year: 2011 PMID： 21670179 PMCID： PMC3165284 DOI： 10.1128/AAC.00122-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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Authors: Alexa A Pragman; Patrick M Schlievert
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8. Effects of subinhibitory concentrations of antibiotics on alpha-toxin (hla) gene expression of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates.

Authors: K Ohlsen; W Ziebuhr; K P Koller; W Hell; T A Wichelhaus; J Hacker
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9. The antimicrobial peptide-sensing system aps of Staphylococcus aureus.

Authors: Min Li; David J Cha; Yuping Lai; Amer E Villaruz; Daniel E Sturdevant; Michael Otto
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10. Effect of antibiotics, alone and in combination, on Panton-Valentine leukocidin production by a Staphylococcus aureus reference strain.

Authors: O Dumitrescu; C Badiou; M Bes; M-E Reverdy; F Vandenesch; J Etienne; G Lina
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Journal: Mol Cell Proteomics Date: 2014-02-24 Impact factor: 5.911

2. Subinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus.

Authors: Eva J Katahira; Stephen M Davidson; Dennis L Stevens; Devin D Bolz
Journal: J Med Microbiol Date: 2018-12-17 Impact factor: 2.472

6. Sub-Inhibitory Concentrations of Oxacillin, but Not Clindamycin, Linezolid, or Tigecycline, Decrease Staphylococcal Phenol-Soluble Modulin Expression in Community-Acquired Methicillin-Resistant Staphylococcus aureus.

Authors: Elisabeth Hodille; Laetitia Beraud; Séverine Périan; Valentine Berti; Michèle Bes; Anne Tristan; Emilie Blond; Gérard Lina; Oana Dumitrescu
Journal: Microbiol Spectr Date: 2022-01-19