OBJECTIVES: To perform a factor analysis using the University of Washington Quality of Life Questionnaire version 4 (UW-QOLv4) to establish subscales; to report their normative values and variations for patients by age, sex, extent of disease, and time from treatment; and to estimate clinical effect sizes and potential for use in comparative treatment studies. DESIGN: Retrospective cohort. SETTING: Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, England. PATIENTS: Patients with primary oral and oropharyngeal cancer treated by surgery with or without adjuvant radiotherapy since 1992. A database accumulating since 1995 contains more than 2600 UW-QOLs completed by these patients. A data set of 372 patients without cancer attending 10 general dental practices provided normative data. MAIN OUTCOME MEASURES: UW-QOLv4. RESULTS: Factor analysis indicated a 2-factor solution: (1) physical function, involving chewing, swallowing, speech, taste, saliva, and appearance, and (2) social-emotional function, involving anxiety, mood, pain, activity, recreation, and shoulder function. The best scores were for those with less advanced oral cancer tumors not requiring free-flap surgery or adjuvant radiotherapy. Older patients reported better scores, but associations were weak, and no sex differences were found. Significant differences were seen for T category, site, free-flap surgery, and adjuvant radiotherapy (P < .001). Preoperative scores were close to normative values. Patients regain social-emotional deficits by 1 year after surgery but continue with significant deficits in physical function. Comparative studies using these UW-QOL subscales as outcome measures should recruit at least 80 patients per treatment arm to detect moderately sized treatment effects. CONCLUSION: With the UW-QOLv4, it is appropriate to analyze and report outcomes using the 2 subscales of physical and social-emotional function.
OBJECTIVES: To perform a factor analysis using the University of Washington Quality of Life Questionnaire version 4 (UW-QOLv4) to establish subscales; to report their normative values and variations for patients by age, sex, extent of disease, and time from treatment; and to estimate clinical effect sizes and potential for use in comparative treatment studies. DESIGN: Retrospective cohort. SETTING: Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, England. PATIENTS: Patients with primary oral and oropharyngeal cancer treated by surgery with or without adjuvant radiotherapy since 1992. A database accumulating since 1995 contains more than 2600 UW-QOLs completed by these patients. A data set of 372 patients without cancer attending 10 general dental practices provided normative data. MAIN OUTCOME MEASURES: UW-QOLv4. RESULTS: Factor analysis indicated a 2-factor solution: (1) physical function, involving chewing, swallowing, speech, taste, saliva, and appearance, and (2) social-emotional function, involving anxiety, mood, pain, activity, recreation, and shoulder function. The best scores were for those with less advanced oral cancer tumors not requiring free-flap surgery or adjuvant radiotherapy. Older patients reported better scores, but associations were weak, and no sex differences were found. Significant differences were seen for T category, site, free-flap surgery, and adjuvant radiotherapy (P < .001). Preoperative scores were close to normative values. Patients regain social-emotional deficits by 1 year after surgery but continue with significant deficits in physical function. Comparative studies using these UW-QOL subscales as outcome measures should recruit at least 80 patients per treatment arm to detect moderately sized treatment effects. CONCLUSION: With the UW-QOLv4, it is appropriate to analyze and report outcomes using the 2 subscales of physical and social-emotional function.
Authors: Marci L Nilsen; Lingyun Lyu; Michael A Belsky; Leila J Mady; Dan P Zandberg; David A Clump; Heath D Skinner; Shyamal Das Peddada; Susan George; Jonas T Johnson Journal: Otolaryngol Head Neck Surg Date: 2019-10-15 Impact factor: 3.497
Authors: Mariana de Pauli Paglioni; Natalia Rangel Palmier; Ana Carolina Prado-Ribeiro; Eduardo Rodrigues Fregnani; Maria Beatriz Duarte Gavião; Thaís Bianca Brandão; Marcio Ajudarte Lopes; Ana Paula Dias Ribeiro; Cesar Augusto Migliorati; Alan Roger Santos-Silva Journal: Support Care Cancer Date: 2019-11-27 Impact factor: 3.603
Authors: Stephanie L Pugh; Gwen Wyatt; Raimond K W Wong; Stephen M Sagar; Bevan Yueh; Anurag K Singh; Min Yao; Phuc Felix Nguyen-Tan; Sue S Yom; Francis S Cardinale; Khalil Sultanem; D Ian Hodson; Greg A Krempl; Ariel Chavez; Alexander M Yeh; Deborah W Bruner Journal: J Pain Symptom Manage Date: 2016-11-27 Impact factor: 3.612
Authors: Tanya L Eadie; Adam M B Day; Devon E Sawin; Kristin Lamvik; Philip C Doyle Journal: Otolaryngol Head Neck Surg Date: 2012-09-24 Impact factor: 3.497
Authors: S N Rogers; R S Pinto; J Lancaster; F Bekiroglu; D Lowe; S Tandon; T M Jones Journal: Eur Arch Otorhinolaryngol Date: 2016-04-18 Impact factor: 2.503