Literature DB >> 20403460

Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells.

Young Soon Lee1, Eun Mi Choi.   

Abstract

Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stimulated SW982 synovial cells. Myricetin significantly decreased IL-1beta-induced production of IL-6 and MMP-1 in synovial cells. Moreover, myricetin diminished the phosphorylation of Jun NH2-terminal kinase (JNK) and p38 MAPK. These results suggest that myricetin reduces the production of MMP and IL-6 in SW982 cells by inhibiting MAPKs (JNK and p38). 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20403460     DOI： 10.1016/j.intimp.2010.04.010

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  10 in total

1.  Myricetin protects against cytokine-induced cell death in RIN-m5f β cells.

Authors:  Ye Ding; Zhao-Feng Zhang; Xiao-Qian Dai; Yong Li
Journal:  J Med Food       Date:  2012-06-25       Impact factor: 2.786

2.  Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet.

Authors:  Ha-Neul Choi; Min-Jung Kang; Soo-Jin Lee; Jung-In Kim
Journal:  Nutr Res Pract       Date:  2014-06-30       Impact factor: 1.926

Review 3.  Myricetin: A Dietary Molecule with Diverse Biological Activities.

Authors:  Deepak Kumar Semwal; Ruchi Badoni Semwal; Sandra Combrinck; Alvaro Viljoen
Journal:  Nutrients       Date:  2016-02-16       Impact factor: 5.717

4.  Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice.

Authors:  Samar M Hassan; Marwa M Khalaf; Sawsan A Sadek; Amira M Abo-Youssef
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

5.  Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats.

Authors:  Muneeb U Rehman; Irfan A Rather
Journal:  Plants (Basel)       Date:  2019-12-24

6.  Myricetin (3,3',4',5,5',7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity.

Authors:  Azher Arafah; Muneeb U Rehman; Ajaz Ahmad; Khalid M AlKharfy; Saeed Alqahtani; Basit L Jan; Nada M Almatroudi
Journal:  ACS Omega       Date:  2022-01-25

7.  Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis.

Authors:  Yanna D Rattmann; Lauro Mera de Souza; Simone M Malquevicz-Paiva; Nessana Dartora; Guilherme Lanzi Sassaki; Philip A J Gorin; Marcello Iacomini
Journal:  Evid Based Complement Alternat Med       Date:  2012-12-20       Impact factor: 2.629

8.  Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5.

Authors:  Udayakumar Karunakaran; Suma Elumalai; Jun Sung Moon; Jae Han Jeon; Nam Doo Kim; Keun Gyu Park; Kyu Chang Won; Jaechan Leem; In Kyu Lee
Journal:  Diabetes Metab J       Date:  2019-01-16       Impact factor: 5.376

9.  Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.

Authors:  Hai-Han Liao; Nan Zhang; Yan-Yan Meng; Hong Feng; Jing-Jing Yang; Wen-Jin Li; Si Chen; Hai-Ming Wu; Wei Deng; Qi-Zhu Tang
Journal:  Oxid Med Cell Longev       Date:  2019-12-06       Impact factor: 6.543

10.  Topical Wound Healing Activity of Myricetin Isolated from Tecomaria capensis v. aurea.

Authors:  Abdelsamed I Elshamy; Naglaa M Ammar; Heba A Hassan; Walaa A El-Kashak; Salim S Al-Rejaie; Ahmed M Abd-ElGawad; Abdel-Razik H Farrag
Journal:  Molecules       Date:  2020-10-22       Impact factor: 4.411
  10 in total

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