Literature DB >> 20402655

Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs.

Xing Zheng1, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo, Duan Fang Liao.   

Abstract

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

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Year:  2010        PMID： 20402655     DOI： 10.2174/157340610791208763

Source DB:  PubMed          Journal:  Med Chem        ISSN： 1573-4064            Impact factor:   2.745


  2 in total

1.  In Silico Screening and Validation of PDGFRA Inhibitors Enhancing Radioiodine Sensitivity in Thyroid Cancer.

Authors:  Xuefei Yu; Xuhang Zhu; Lizhuo Zhang; Jiang-Jiang Qin; Chunlai Feng; Qinglin Li
Journal:  Front Pharmacol       Date:  2022-05-12       Impact factor: 5.988

2.  A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.

Authors:  Haidan Liu; Joonsung Hwang; Wei Li; Tae Woong Choi; Kangdong Liu; Zunnan Huang; Jae-Hyuk Jang; N R Thimmegowda; Ki Won Lee; In-Ja Ryoo; Jong-Seog Ahn; Ann M Bode; Xinmin Zhou; Yifeng Yang; Raymond L Erikson; Bo-Yeon Kim; Zigang Dong
Journal:  Cancer Prev Res (Phila)       Date:  2013-10-29
  2 in total

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