Literature DB >> 20399696

Two FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndrome.

Jing Du1, Wenjing Zhang, Lingli Guo, Zhaofeng Zhang, Huijuan Shi, Jian Wang, Huiqin Zhang, Linghan Gao, Guoyin Feng, Lin He.   

Abstract

In this study, two polymorphisms of follicle stimulating hormone receptor (FSHR) gene were analysed in the case-control sample using 40 premature ovarian failure (POF) patients, 60 polycystic ovary syndrome (PCOS) patients and 92 healthy controls. All subjects were unrelated Han Chinese from Shanghai. No difference was observed on the allelic or genotypic distribution of FSHR gene polymorphisms between the groups. However, the two-marker haplotypes covering components Thr307Ala (rs6165) G and Asn680Ser (rs6166) A were observed to be significantly associated with PCOS (p=0.007, corrected p=0.042). Meanwhile, a meta-analysis including our study (altogether six POF and eight PCOS studies) showed significant association between rs6166 marker and PCOS (p<0.05). The results suggest that FSH receptor might play a role in genetic susceptibility to PCOS. However, confirmatory studies in independent samples are needed. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20399696     DOI： 10.1016/j.ymgme.2010.03.018

Source DB:  PubMed          Journal:  Mol Genet Metab        ISSN： 1096-7192            Impact factor:   4.797


  26 in total

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Authors:  R Saxena; N A Georgopoulos; T J Braaten; A C Bjonnes; V Koika; D Panidis; C K Welt
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3.  Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome.

Authors:  Wassim Y Almawi; Bayan Hubail; Dana Z Arekat; Suhaila M Al-Farsi; Shadha K Al-Kindi; Mona R Arekat; Naeema Mahmood; Samira Madan
Journal:  J Assist Reprod Genet       Date:  2015-02-04       Impact factor: 3.412

Review 4.  Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function.

Authors:  Livio Casarini; Elisa Pignatti; Manuela Simoni
Journal:  Rev Endocr Metab Disord       Date:  2011-12       Impact factor: 6.514

5.  FSH-receptor Ala307Thr polymorphism is associated to polycystic ovary syndrome and to a higher responsiveness to exogenous FSH in Italian women.

Authors:  Elisabetta Dolfin; Benedetta Guani; Cristina Lussiana; Caterina Mari; Gabriella Restagno; Alberto Revelli
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6.  Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.

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7.  FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome.

Authors:  Jin Ju Kim; Young Min Choi; Min A Hong; Soo Jin Chae; Kyuri Hwang; Sang Ho Yoon; Seung Yup Ku; Chang Suk Suh; Seok Hyun Kim
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Review 8.  Pharmacogenetics of follicle-stimulating hormone action.

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9.  Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.

Authors:  Lingyuan Fu; Zhaofeng Zhang; Aiping Zhang; Jianhua Xu; Xianliang Huang; Qiupeng Zheng; Yunlei Cao; Lei Wang; Jing Du
Journal:  J Assist Reprod Genet       Date:  2013-03-29       Impact factor: 3.412

10.  Impact of follicle-stimulating hormone receptor variants in female infertility.

Authors:  Nermin Seda Ilgaz; Oya Sena Erdogan Aydos; Aynur Karadag; Mehmet Taspinar; Ozlem Gun Eryilmaz; Asuman Sunguroglu
Journal:  J Assist Reprod Genet       Date:  2015-09-24       Impact factor: 3.412
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