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Literature DB >> 20392284

Therapeutics for cognitive aging.

Diana W Shineman¹, Timothy A Salthouse, Lenore J Launer, Patrick R Hof, George Bartzokis, Robin Kleiman, Victoria Luine, Jerry J Buccafusco, Gary W Small, Paul S Aisen, David A Lowe, Howard M Fillit.

Abstract

This review summarizes the scientific talks presented at the conference "Therapeutics for Cognitive Aging," hosted by the New York Academy of Sciences and the Alzheimer's Drug Discovery Foundation on May 15, 2009. Attended by scientists from industry and academia, as well as by a number of lay people-approximately 200 in all-the conference specifically tackled the many aspects of developing therapeutic interventions for cognitive impairment. Discussion also focused on how to define cognitive aging and whether it should be considered a treatable, tractable disease.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2010 PMID： 20392284 PMCID： PMC3107251 DOI： 10.1111/j.1749-6632.2010.05532.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

48 in total

1. Association of KIBRA and memory.

Authors: Timothy C Bates; Jackie F Price; Sarah E Harris; Riccardo E Marioni; F Gerry R Fowkes; Marlene C Stewart; Gordon D Murray; Lawrence J Whalley; John M Starr; Ian J Deary
Journal: Neurosci Lett Date: 2009-05-03 Impact factor: 3.046

2. The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging.

Authors: Doron Kabaso; Patrick J Coskren; Bruce I Henry; Patrick R Hof; Susan L Wearne
Journal: Cereb Cortex Date: 2009-01-15 Impact factor: 5.357

3. Global prevalence of dementia: a Delphi consensus study.

Authors: Cleusa P Ferri; Martin Prince; Carol Brayne; Henry Brodaty; Laura Fratiglioni; Mary Ganguli; Kathleen Hall; Kazuo Hasegawa; Hugh Hendrie; Yueqin Huang; Anthony Jorm; Colin Mathers; Paulo R Menezes; Elizabeth Rimmer; Marcia Scazufca
Journal: Lancet Date: 2005-12-17 Impact factor: 79.321

4. Age-related top-down suppression deficit in the early stages of cortical visual memory processing.

Authors: Adam Gazzaley; Wesley Clapp; Jon Kelley; Kevin McEvoy; Robert T Knight; Mark D'Esposito
Journal: Proc Natl Acad Sci U S A Date: 2008-09-02 Impact factor: 11.205

Review 5. Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

Authors: George Bartzokis
Journal: Neurobiol Aging Date: 2009-09-22 Impact factor: 4.673

6. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.

Authors: Richard J Caselli; Amylou C Dueck; David Osborne; Marwan N Sabbagh; Donald J Connor; Geoffrey L Ahern; Leslie C Baxter; Steven Z Rapcsak; Jiong Shi; Bryan K Woodruff; Dona E C Locke; Charlene Hoffman Snyder; Gene E Alexander; Rosa Rademakers; Eric M Reiman
Journal: N Engl J Med Date: 2009-07-16 Impact factor: 91.245

7. Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.

Authors: Nelleke Tolboom; Wiesje M van der Flier; Maqsood Yaqub; Ronald Boellaard; Nicolaas A Verwey; Marinus A Blankenstein; Albert D Windhorst; Philip Scheltens; Adriaan A Lammertsma; Bart N M van Berckel
Journal: J Nucl Med Date: 2009-08-18 Impact factor: 10.057

Therapeutics for cognitive aging.

1. Association of KIBRA and memory.

2. The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging.

3. Global prevalence of dementia: a Delphi consensus study.

4. Age-related top-down suppression deficit in the early stages of cortical visual memory processing.

Review 5. Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

6. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.

7. Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.

Review 8. The synaptic organization of the neocortex in Alzheimer's disease.

9. Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging.

Review 10. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.

1. Brain axial and radial diffusivity changes with age and gender in healthy adults.

2. Nutraceutical intervention improves older adults' cognitive functioning.

Review 3. Redefining Aging in HIV Infection Using Phenotypes.