OBJECTIVE: To examine the association between total antioxidant capacity (TAC) intake and colorectal cancer incidence. METHODS: TAC intake was assessed in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study, a prospective cohort study of 47,339 men. Between 1986 and 2004, 952 colorectal cancer cases were diagnosed. Cox proportional hazards regression models were used to estimate relative risks (RR) and 95% confidence intervals (CI). RESULTS: Comparing the highest versus lowest quintile, TAC intake from foods only (dietary TAC) was not associated with colorectal (multivariate-RR: 0.98; 95% CI: 0.78, 1.23) or colon (multivariate-RR: 1.20; 95% CI: 0.90, 1.61) cancer risk, but was inversely associated with rectal cancer risk (multivariate-RR: 0.58; 95% CI: 0.35, 0.96). For the same comparison, TAC intake from foods and supplements (total TAC) was not associated with colorectal (multivariate-RR: 0.91; 95% CI: 0.73, 1.14), colon (multivariate-RR: 1.01; 95% CI: 0.77, 1.33), or rectal (multivariate-RR: 0.85; 95% CI: 0.52, 1.38) cancer risk. CONCLUSIONS: Dietary and total TAC intakes were not associated with colorectal and colon cancer risk. Dietary, but not total, TAC intake was inversely associated with rectal cancer risk, suggesting antioxidants per se may not be associated with rectal cancer risk.
OBJECTIVE: To examine the association between total antioxidant capacity (TAC) intake and colorectal cancer incidence. METHODS: TAC intake was assessed in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study, a prospective cohort study of 47,339 men. Between 1986 and 2004, 952 colorectal cancer cases were diagnosed. Cox proportional hazards regression models were used to estimate relative risks (RR) and 95% confidence intervals (CI). RESULTS: Comparing the highest versus lowest quintile, TAC intake from foods only (dietary TAC) was not associated with colorectal (multivariate-RR: 0.98; 95% CI: 0.78, 1.23) or colon (multivariate-RR: 1.20; 95% CI: 0.90, 1.61) cancer risk, but was inversely associated with rectal cancer risk (multivariate-RR: 0.58; 95% CI: 0.35, 0.96). For the same comparison, TAC intake from foods and supplements (total TAC) was not associated with colorectal (multivariate-RR: 0.91; 95% CI: 0.73, 1.14), colon (multivariate-RR: 1.01; 95% CI: 0.77, 1.33), or rectal (multivariate-RR: 0.85; 95% CI: 0.52, 1.38) cancer risk. CONCLUSIONS: Dietary and total TAC intakes were not associated with colorectal and colon cancer risk. Dietary, but not total, TAC intake was inversely associated with rectal cancer risk, suggesting antioxidants per se may not be associated with rectal cancer risk.
Authors: Bente L Halvorsen; Kari Holte; Mari C W Myhrstad; Ingrid Barikmo; Erlend Hvattum; Siv Fagertun Remberg; Anne-Brit Wold; Karin Haffner; Halvard Baugerød; Lene Frost Andersen; Ø Moskaug; David R Jacobs; Rune Blomhoff Journal: J Nutr Date: 2002-03 Impact factor: 4.798
Authors: P K Newby; Frank B Hu; Eric B Rimm; Stephanie A Smith-Warner; Diane Feskanich; Laura Sampson; Walter C Willett Journal: Am J Clin Nutr Date: 2003-11 Impact factor: 7.045
Authors: Esther K Wei; Edward Giovannucci; Kana Wu; Bernard Rosner; Charles S Fuchs; Walter C Willett; Graham A Colditz Journal: Int J Cancer Date: 2004-01-20 Impact factor: 7.396
Authors: Harold E Seifried; Sharon S McDonald; Darrell E Anderson; Peter Greenwald; John A Milner Journal: Cancer Res Date: 2003-08-01 Impact factor: 12.701
Authors: Dina Gifkins; Sara H Olson; Kitaw Demissie; Shou-En Lu; Ah-Ng Tony Kong; Elisa V Bandera Journal: Cancer Causes Control Date: 2012-04-19 Impact factor: 2.506
Authors: Amy J Schulz; Graciela B Mentz; Natalie R Sampson; J Timothy Dvonch; Angela G Reyes; Betty Izumi Journal: Am J Public Health Date: 2014-10-16 Impact factor: 9.308
Authors: Kjell M Russnes; Elisabeth Möller; Kathryn M Wilson; Monica Carlsen; Rune Blomhoff; Sigbjørn Smeland; Hans-Olov Adami; Henrik Grönberg; Lorelei A Mucci; Katarina Bälter Journal: BMC Cancer Date: 2016-07-11 Impact factor: 4.430
Authors: Daniel Barbosa Coelho; Lilian Maria Peixoto Lopes; Emerson Cruz de Oliveira; Lenice Kappes Becker; Guilherme de Paula Costa; Helen Hermana Miranda Hermsdorff; Fernanda Guimarães Drummond E Silva; Kelerson Mauro de Castro Pinto; André Talvani; Júlia Cristina Cardoso Carraro Journal: Biomed Res Int Date: 2021-11-25 Impact factor: 3.411