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Literature DB >> 20390279

Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis.

Wei-Ping Chen¹, Jia-Peng Bao, Jin-Li Tang, Peng-Fei Hu, Li-Dong Wu.

Abstract

The aim of this study was to investigate the effects of trichostatin A (TSA) on expression of cathepsins in cartilage in experimental osteoarthritis (OA). OA was induced in 18 rabbits by bilateral anterior cruciate ligament transection (ACLT). Four weeks after surgery, rabbits received intra-articular injection with TSA dissolved in the dimethylsulphoxide (DMSO) in the right knees and DMSO in the left knees once a week for 5 weeks. Rabbits were killed 7 days after the last injection. The knee joints were assessed by morphological and histological examination. Messenger RNA expression of cathepsins K, B, L, S and cystatin C was studied by real-time PCR. TSA inhibited the expression of cathepsins K, B, L, S and cystatin C accompanied with the less degradation in cartilage. The results suggest that TSA exhibits protective effects against cartilage degradation in rabbits with OA and the effects may be associated with the inhibition of cathepsins.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 20390279 DOI： 10.1007/s00296-010-1481-7

Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631

35 in total

Review 1. Cathepsin B in osteoarthritis: uncontrolled proteolysis in the wrong place.

Authors: Antonio Baici; Angela Lang; Roman Zwicky; Kathrin Müntener
Journal: Semin Arthritis Rheum Date: 2005-06 Impact factor: 5.532

2. Cathepsins B, K, and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes.

Authors: Anke Ruettger; Susann Schueler; Juergen A Mollenhauer; Bernd Wiederanders
Journal: J Biol Chem Date: 2007-11-08 Impact factor: 5.157

3. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.

Authors: Q Nguyen; J S Mort; P J Roughley
Journal: Biochem J Date: 1990-03-01 Impact factor: 3.857

4. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.

Authors: M D Tortorella; A M Malfait; C Deccico; E Arner
Journal: Osteoarthritis Cartilage Date: 2001-08 Impact factor: 6.576

5. Osteoarthritis cartilage histopathology: grading and staging.

Authors: K P H Pritzker; S Gay; S A Jimenez; K Ostergaard; J-P Pelletier; P A Revell; D Salter; W B van den Berg
Journal: Osteoarthritis Cartilage Date: 2005-10-19 Impact factor: 6.576

6. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.

Authors: Haihong Zhong; Michael J May; Eijiro Jimi; Sankar Ghosh
Journal: Mol Cell Date: 2002-03 Impact factor: 17.970

Review 7. The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.

Authors: Yoshiyuki Yasuda; Jadwiga Kaleta; Dieter Brömme
Journal: Adv Drug Deliv Rev Date: 2005-04-15 Impact factor: 15.470

8. Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model.

Authors: Yongseok Choi; Song-Kyu Park; Hwan Mook Kim; Jong Soon Kang; Yeo Dae Yoon; Sang Bae Han; Jeung Whan Han; Jee Sun Yang; Gyoonhee Han
Journal: Exp Mol Med Date: 2008-10-31 Impact factor: 8.718

9. Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation.

Authors: Wu-Shiun Hou; Zhenqiang Li; Frank H Büttner; Eckart Bartnik; Dieter Brömme
Journal: Biol Chem Date: 2003-06 Impact factor: 3.915

10. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.

Authors: Y Nasu; K Nishida; S Miyazawa; T Komiyama; Y Kadota; N Abe; A Yoshida; S Hirohata; A Ohtsuka; T Ozaki
Journal: Osteoarthritis Cartilage Date: 2008-01-15 Impact factor: 6.576

6 in total

Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis.

Review 1. Cathepsin B in osteoarthritis: uncontrolled proteolysis in the wrong place.

2. Cathepsins B, K, and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes.

3. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.

4. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.

5. Osteoarthritis cartilage histopathology: grading and staging.

6. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.

Review 7. The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.

8. Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model.

9. Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation.

10. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.

Review 1. Histone Deacetylases in Bone Development and Skeletal Disorders.

Review 2. Histone Deacetylases in Cartilage Homeostasis and Osteoarthritis.

Review 3. Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.

4. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease.

Review 5. Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications.

6. MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis.