Literature DB >> 20387084

On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079.

Daniel Marcellino1, Diana Suárez-Boomgaard, María Dolores Sánchez-Reina, José A Aguirre, Takashi Yoshitake, Shimako Yoshitake, Beth Hagman, Jan Kehr, Luigi F Agnati, Kjell Fuxe, Alicia Rivera.   

Abstract

The role of the ATP-gated receptor, P2X(7), has been evaluated in the unilateral 6-OHDA rat model of Parkinson's disease using the P2X(7) competitive antagonist A-438079. Nigral P2X(7) immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation.

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Year:  2010        PMID： 20387084     DOI： 10.1007/s00702-010-0400-0

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  20 in total

Review 1.  The nigrostriatal DA pathway and Parkinson's disease.

Authors:  K Fuxe; P Manger; S Genedani; L Agnati
Journal:  J Neural Transm Suppl       Date:  2006

Review 2.  A new road to neuroinflammation in Parkinson's disease?

Authors:  Kjell G Fuxe; Alexander O Tarakanov; Larisa B Goncharova; Luigi F Agnati
Journal:  Brain Res Rev       Date:  2008-04-11

Review 3.  Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons.

Authors:  Christopher M Anderson; Maiken Nedergaard
Journal:  Trends Neurosci       Date:  2006-03-27       Impact factor: 13.837

4.  A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.

Authors:  Prisca Honore; Diana Donnelly-Roberts; Marian T Namovic; Gin Hsieh; Chang Z Zhu; Joe P Mikusa; Gricelda Hernandez; Chengmin Zhong; Donna M Gauvin; Prasant Chandran; Richard Harris; Arturo Perez Medrano; William Carroll; Kennan Marsh; James P Sullivan; Connie R Faltynek; Michael F Jarvis
Journal:  J Pharmacol Exp Ther       Date:  2006-09-18       Impact factor: 4.030

5.  Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.

Authors:  Pablo Pelegrin; Annmarie Surprenant
Journal:  EMBO J       Date:  2006-10-12       Impact factor: 11.598

6.  Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice.

Authors:  Jesús Sánchez-Nogueiro; Patricia Marín-García; M Teresa Miras-Portugal
Journal:  FEBS Lett       Date:  2005-07-04       Impact factor: 4.124

7.  The novel cyclooxygenase-2 inhibitor GW637185X protects against l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.

Authors:  Jose A Aguirre; Giuseppina Leo; Raquel Cueto; Beth Andbjer; Alan Naylor; Andrew D Medhurst; Luigi F Agnati; Kjell Fuxe
Journal:  Neuroreport       Date:  2008-04-16       Impact factor: 1.837

Review 8.  The P2X7 receptor: a key player in IL-1 processing and release.

Authors:  Davide Ferrari; Cinzia Pizzirani; Elena Adinolfi; Roberto M Lemoli; Antonio Curti; Marco Idzko; Elisabeth Panther; Francesco Di Virgilio
Journal:  J Immunol       Date:  2006-04-01       Impact factor: 5.422

9.  Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding.

Authors:  L Acarin; J M Vela; B González; B Castellano
Journal:  J Histochem Cytochem       Date:  1994-08       Impact factor: 2.479

10.  Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.

Authors:  Dong-Jae Jun; Jaeyoon Kim; Sang-Yong Jung; Ran Song; Ji-Hyun Noh; Yong-Soo Park; Sung-Ho Ryu; Joung-Hun Kim; Young-Yun Kong; Jun-Mo Chung; Kyong-Tai Kim
Journal:  J Biol Chem       Date:  2007-10-25       Impact factor: 5.157
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  29 in total

1.  The impact of commercially available purinergic ligands on purinergic signalling research.

Authors:  J R Flanaghan; S J Roome
Journal:  Purinergic Signal       Date:  2011-10-27       Impact factor: 3.765

Review 2.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

3.  Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease.

Authors:  Enéas G Ferrazoli; Héllio D N de Souza; Isis C Nascimento; Ágatha Oliveira-Giacomelli; Telma T Schwindt; Luiz R Britto; Henning Ulrich
Journal:  Cell Transplant       Date:  2017-04-13       Impact factor: 4.064

4.  Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease.

Authors:  Marta Carmo; Francisco Q Gonçalves; Paula M Canas; Jean-Pierre Oses; Francisco D Fernandes; Filipe V Duarte; Carlos M Palmeira; Angelo R Tomé; Paula Agostinho; Geanne M Andrade; Rodrigo A Cunha
Journal:  Br J Pharmacol       Date:  2019-08-01       Impact factor: 8.739

5.  The hydrolysis of striatal adenine- and guanine-based purines in a 6-hydroxydopamine rat model of Parkinson's disease.

Authors:  Jean Pierre Oses; Cristiane Batassini; Daniela Pochmann; Ana Elisa Böhmer; Fernanda Cenci Vuaden; Roberta Bristot Silvestrin; Alcyr Oliveira; Carla Denise Bonan; Maurício Reis Bogo; Diogo Onofre Souza; Luis Valmor Cruz Portela; João José de Freitas Sarkis; Tadeu Mello e Souza
Journal:  Neurochem Res       Date:  2010-11-04       Impact factor: 3.996

6.  The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice.

Authors:  J P Martins; R B M Silva; R Coutinho-Silva; C M Takiya; A M O Battastini; F B Morrone; M M Campos
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

Review 7.  P2X7 as a scavenger receptor for innate phagocytosis in the brain.

Authors:  Ben J Gu; James S Wiley
Journal:  Br J Pharmacol       Date:  2018-10-05       Impact factor: 8.739

Review 8.  Pathophysiology of astroglial purinergic signalling.

Authors:  Heike Franke; Alexei Verkhratsky; Geoffrey Burnstock; Peter Illes
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

Review 9.  Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease.

Authors:  Talita Glaser; Roberta Andrejew; Ágatha Oliveira-Giacomelli; Deidiane Elisa Ribeiro; Lucas Bonfim Marques; Qing Ye; Wen-Jing Ren; Alexey Semyanov; Peter Illes; Yong Tang; Henning Ulrich
Journal:  Neurosci Bull       Date:  2020-10-07       Impact factor: 5.203

10.  Inflammatory Pathways in Parkinson's Disease; A BNE Microarray Study.

Authors:  Pascal F Durrenberger; Edna Grünblatt; Francesca S Fernando; Camelia Maria Monoranu; Jordan Evans; Peter Riederer; Richard Reynolds; David T Dexter
Journal:  Parkinsons Dis       Date:  2012-04-02
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