Literature DB >> 15978588

Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice.

Jesús Sánchez-Nogueiro1, Patricia Marín-García, M Teresa Miras-Portugal.   

Abstract

The presence of ionotropic P2X(7) receptor has been studied in mice brain from wild type and P2X(7) receptor knockout animals. Western blot and immunocytochemical assays show the presence of a protein containing the P2X(7) immunogenic epitopes in the brain of knockout model. Reverse transcriptase polymerase chain reaction experiments demonstrate the absence of the disrupted sequence, but other sequences of P2X(7) specific mRNA expression have been detected. Functional calcium imaging experiments in cultured granule neurons from P2X(7) knockout cerebella show the existence of a functional P2X(7)-like receptor that keeps some of the properties of the genuine receptor.

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Year:  2005        PMID： 15978588     DOI： 10.1016/j.febslet.2005.05.073

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  28 in total

Review 1.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

Review 2.  Purinergic modulation of granule cells.

Authors:  Raphaël Courjaret; María Teresa Miras-Portugal; Joachim W Deitmer
Journal:  Cerebellum       Date:  2012-03       Impact factor: 3.847

3.  On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079.

Authors:  Daniel Marcellino; Diana Suárez-Boomgaard; María Dolores Sánchez-Reina; José A Aguirre; Takashi Yoshitake; Shimako Yoshitake; Beth Hagman; Jan Kehr; Luigi F Agnati; Kjell Fuxe; Alicia Rivera
Journal:  J Neural Transm (Vienna)       Date:  2010-04-13       Impact factor: 3.575

4.  Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia.

Authors:  W Nörenberg; J Schunk; W Fischer; H Sobottka; T Riedel; J F Oliveira; H Franke; P Illes
Journal:  Br J Pharmacol       Date:  2010-08       Impact factor: 8.739

5.  Role of CaCMKII in the cross talk between ionotropic nucleotide and nicotinic receptors in individual cholinergic terminals.

Authors:  M Díaz-Hernández; J Sánchez-Nogueiro; M T Miras-Portugal
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

6.  P2 receptors in renal pathophysiology.

Authors:  Clare M Turner; James I Elliott; Frederick W K Tam
Journal:  Purinergic Signal       Date:  2009-06-09       Impact factor: 3.765

7.  Physiological and pathological functions of P2X7 receptor in the spinal cord.

Authors:  Maria Luisa Cotrina; Maiken Nedergaard
Journal:  Purinergic Signal       Date:  2009-02-11       Impact factor: 3.765

8.  P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotection in cerebellar granule neurons.

Authors:  Felipe Ortega; Raquel Pérez-Sen; Esmerilda G Delicado; M Teresa Miras-Portugal
Journal:  Neurotox Res       Date:  2009-02-24       Impact factor: 3.911

Review 9.  Activation and regulation of purinergic P2X receptor channels.

Authors:  Claudio Coddou; Zonghe Yan; Tomas Obsil; J Pablo Huidobro-Toro; Stanko S Stojilkovic
Journal:  Pharmacol Rev       Date:  2011-07-07       Impact factor: 25.468

10.  P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.

Authors:  Tobias Engel; Alba Jimenez-Pacheco; Maria Teresa Miras-Portugal; Miguel Diaz-Hernandez; David C Henshall
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2012-12-26
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