Meike Ressing1, Maria Blettner, Stefanie J Klug. 1. Institut für Medizinische Biometrie, Epidemiologie und Informatik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany.
Abstract
INTRODUCTION: An important objective of epidemiological research is to identify risk factors for disease. Depending on the particular question being asked, cohort studies, case-control studies, or cross-sectional studies are conducted. METHODS: Methods of data analysis in different types of epidemiological studies are illustrated through examples with fictive data. Important measures of frequency and effect will be introduced. Different regression models will be presented as examples of complex analytical methods. RESULTS: Important frequency measures in cohort studies are incidence and mortality. Important effect measures such as the relative risk (RR), hazard ratio (HR), standardized incidence ratio (SIR), standardized mortality ratio (SMR), and odds ratio (OR) can also be calculated. In case-control or cross-sectional studies, the OR can be calculated as an effect measure. In cross-sectional studies, prevalence is the most important frequency measure. The interpretation of different frequency measures and effect measures will be discussed. CONCLUSION: The measures to be calculated and the analyses to be performed in an epidemiological study depend on the research questions being asked, the study type, and the available data.
INTRODUCTION: An important objective of epidemiological research is to identify risk factors for disease. Depending on the particular question being asked, cohort studies, case-control studies, or cross-sectional studies are conducted. METHODS: Methods of data analysis in different types of epidemiological studies are illustrated through examples with fictive data. Important measures of frequency and effect will be introduced. Different regression models will be presented as examples of complex analytical methods. RESULTS: Important frequency measures in cohort studies are incidence and mortality. Important effect measures such as the relative risk (RR), hazard ratio (HR), standardized incidence ratio (SIR), standardized mortality ratio (SMR), and odds ratio (OR) can also be calculated. In case-control or cross-sectional studies, the OR can be calculated as an effect measure. In cross-sectional studies, prevalence is the most important frequency measure. The interpretation of different frequency measures and effect measures will be discussed. CONCLUSION: The measures to be calculated and the analyses to be performed in an epidemiological study depend on the research questions being asked, the study type, and the available data.
Authors: Martina Sanlorenzo; Mackenzie R Wehner; Eleni Linos; John Kornak; Wolfgang Kainz; Christian Posch; Igor Vujic; Katia Johnston; Deborah Gho; Gabriela Monico; James T McGrath; Simona Osella-Abate; Pietro Quaglino; James E Cleaver; Susana Ortiz-Urda Journal: JAMA Dermatol Date: 2015-01 Impact factor: 10.282