| Literature DB >> 20385185 |
Dana L Nettles1, Ashutosh Chilkoti, Lori A Setton.
Abstract
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.Entities:
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Year: 2010 PMID： 20385185 PMCID： PMC2935943 DOI： 10.1016/j.addr.2010.04.002
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470