Literature DB >> 20383271

Biomarkers of oxidative damage and inflammation in Alzheimer's disease.

Douglas Galasko1, Thomas J Montine.   

Abstract

Oxidative damage and inflammation are important features of the brain pathology of Alzheimer's disease (AD). Oxidative damage can be found in membranes (lipid peroxidation), proteins (nitrosylation and other post-translational changes) and nucleic acids. Inflammatory changes include activation of microglia and astrocytes, with increased levels of proinflammatory cytokines. Not all of these changes are specific to AD, and occur in other neurodegenerative disorders. Both oxidative stress and inflammation are potential therapeutic targets in AD, and biomarkers could help to identify and monitor key pathways in patients with AD. This article summarizes progress in developing cerebrospinal fluid biomarkers related to oxidative stress and inflammation, problems and pitfalls related to systemic (blood- or urine-based) biomarkers in this area, and future research directions and applications.

Entities:  

Keywords:  Alzheimer’s disease; F2-isoprostanes; biomarker; cytokines; oxidative stress

Mesh：

Substances：

Year:  2010        PMID： 20383271      PMCID： PMC2850111          DOI： 10.2217/bmm.09.89

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  59 in total

1.  Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients.

Authors:  E Rota; G Bellone; P Rocca; B Bergamasco; G Emanuelli; P Ferrero
Journal:  Neurol Sci       Date:  2006-04       Impact factor: 3.307

2.  Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms.

Authors:  A-M Nilselid; Pia Davidsson; Katarina Nägga; Niels Andreasen; Pam Fredman; Kaj Blennow
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3.  Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia.

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Journal:  Acta Neurol Scand       Date:  2001-03       Impact factor: 3.209

Review 4.  Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid.

Authors:  C E Teunissen; J de Vente; H W M Steinbusch; C De Bruijn
Journal:  Neurobiol Aging       Date:  2002 Jul-Aug       Impact factor: 4.673

5.  Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

Authors:  D Blum-Degen; T Müller; W Kuhn; M Gerlach; H Przuntek; P Riederer
Journal:  Neurosci Lett       Date:  1995-12-29       Impact factor: 3.046

6.  Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease.

Authors:  E R Peskind; W S Griffin; K T Akama; M A Raskind; L J Van Eldik
Journal:  Neurochem Int       Date:  2001 Nov-Dec       Impact factor: 3.921

7.  Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease.

Authors:  Estrella Gómez-Tortosa; Isabel Gonzalo; Samira Fanjul; Maria José Sainz; Susana Cantarero; Carlos Cemillán; Justo García Yébenes; Teodoro del Ser
Journal:  Arch Neurol       Date:  2003-09

Review 8.  Biological and methodological features of the measurement of S100B, a putative marker of brain injury.

Authors:  Carlos-Alberto Gonçalves; Marina Concli Leite; Patrícia Nardin
Journal:  Clin Biochem       Date:  2008-04-18       Impact factor: 3.281

9.  Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease.

Authors:  Julius Popp; Michael Bacher; Heike Kölsch; Carmen Noelker; Oliver Deuster; Richard Dodel; Frank Jessen
Journal:  J Psychiatr Res       Date:  2008-11-26       Impact factor: 4.791

10.  Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Authors:  Takashi Abe; Hideo Tohgi; Chiaki Isobe; Takahiko Murata; Chigumi Sato
Journal:  J Neurosci Res       Date:  2002-11-01       Impact factor: 4.164
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  68 in total

Review 1.  Neuroprotective strategies involving ROS in Alzheimer disease.

Authors:  Magali Dumont; M Flint Beal
Journal:  Free Radic Biol Med       Date:  2010-12-01       Impact factor: 7.376

2.  Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.

Authors:  Nicolas G Bazan; Miguel F Molina; William C Gordon
Journal:  Annu Rev Nutr       Date:  2011-08-21       Impact factor: 11.848

Review 3.  Progress update: fluid and imaging biomarkers in Alzheimer's disease.

Authors:  Courtney L Sutphen; Anne M Fagan; David M Holtzman
Journal:  Biol Psychiatry       Date:  2013-09-05       Impact factor: 13.382

4.  The effect of progesterone dose on gene expression after traumatic brain injury.

Authors:  Gail D Anderson; Federico M Farin; Theo K Bammler; Richard P Beyer; Alicia A Swan; Hui-Wen Wilkerson; Eric D Kantor; Michael R Hoane
Journal:  J Neurotrauma       Date:  2011-09-08       Impact factor: 5.269

Review 5.  Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment.

Authors:  Luis F Gonzalez-Cuyar; Joshua A Sonnen; Kathleen S Montine; C Dirk Keene; Thomas J Montine
Journal:  Curr Neurol Neurosci Rep       Date:  2011-10       Impact factor: 5.081

Review 6.  Anesthetic modulation of neuroinflammation in Alzheimer's disease.

Authors:  Junxia X Tang; Maryellen F Eckenhoff; Roderic G Eckenhoff
Journal:  Curr Opin Anaesthesiol       Date:  2011-08       Impact factor: 2.706

Review 7.  Diabetes and cognition.

Authors:  Elizabeth Rose Mayeda; Rachel A Whitmer; Kristine Yaffe
Journal:  Clin Geriatr Med       Date:  2014-11-15       Impact factor: 3.076

8.  Mangiferin decreases inflammation and oxidative damage in rat brain after stress.

Authors:  Lucía Márquez; Borja García-Bueno; José L M Madrigal; Juan C Leza
Journal:  Eur J Nutr       Date:  2011-10-07       Impact factor: 5.614

Review 9.  The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation.

Authors:  Eugenio Barone; Fabio Di Domenico; Cesare Mancuso; D Allan Butterfield
Journal:  Neurobiol Dis       Date:  2013-10-02       Impact factor: 5.996

10.  Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging.

Authors:  Debjani Tripathy; Xiangling Yin; Alma Sanchez; Jinhua Luo; Joseph Martinez; Paula Grammas
Journal:  J Neuroinflammation       Date:  2010-10-11       Impact factor: 8.322
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