| Literature DB >> 25453304 |
Elizabeth Rose Mayeda1, Rachel A Whitmer2, Kristine Yaffe3.
Abstract
Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.Entities:
Keywords: Aging; Cognition; Cognitive decline; Dementia; Epidemiology; Type 2 diabetes
Mesh:
Year: 2014 PMID: 25453304 PMCID: PMC4370221 DOI: 10.1016/j.cger.2014.08.021
Source DB: PubMed Journal: Clin Geriatr Med ISSN: 0749-0690 Impact factor: 3.076