| Literature DB >> 20382006 |
Geraldo Célio Brandão1, Erna Gessien Kroon, Maria Gorette R Duarte, Fernão Castro Braga, José Dias de Souza Filho, Alaíde Braga de Oliveira.
Abstract
Polygonum spectabile is used in Brazil for treatment of several infection diseases. Extracts and constituents isolated from this species were evaluated for cytotoxicity and effects on 15 bacterias and yeasts as well on 4 viruses strains (HHV-1, VACV-WR, EMCV, DEN-2). Less polar extracts were effective against Staphylococcus aureus, Bacillus subtillis, Micrococcus luteus, M. canis and Tricophyton mentagrophytes and T. rubrum. Two known chalcones and 3-O-β-D-glucosyl-β-sitosterol were isolated. The ethanol extract was the only one to show antiviral activity (CE50 < 30 μg/ml). One chalcone has inhibited the growth of several bacteria and was significantly active against dermathophytes. The 3 compounds isolated have shown moderate cytotoxicity against Vero and LLCMK(2) cells (CC(50) < 50 μg/ml). These results support the use of P. spectabile as antimicrobial agent. 2010 Elsevier GmbH. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20382006 DOI： 10.1016/j.phymed.2010.03.004
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340