E Noé1, J Ferri, C Colomer, B Moliner, J Chirivella. 1. Servicio de Daño Cerebral de los Hospitales NISA, Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Hospital Valencia al Mar, Valencia, Spain. enoe@comv.es
Abstract
OBJECTIVE: To determine if APOE genotype is linked to memory function after moderate-severe traumatic brain injury (TBI). METHODS: Eighty-two patients in post-traumatic amnesia (PTA) and 107 patients who had emerged from PTA were selected from 239 consecutive patients admitted to the facility. Verbal memory assessments, including the Spanish version of the California Verbal Learning Test and the Working-Memory Index of the WAIS-III, were conducted immediately after PTA resolution or during the first week after admission for patients who were out of PTA. Both groups were reassessed 6 months after inclusion in a multidisciplinary rehabilitation programme. RESULTS: Patients with the APOE-epsilon 4 allele (n = 17 in the PTA group and n = 9 in the out of PTA group) entered rehabilitation at a more impaired level, but made remarkable progress during follow-up. Fifty-five patients from the initial sample emerged from PTA during the follow-up period. Age, GOAT at admission and chronicity, but not APOE genotype or initial trauma severity, were significant predictors of emergence from PTA. CONCLUSIONS: APOE genotype seems to be associated with the trajectory of cognitive recovery after TBI, but does not play a determinant role in the efficacy of memory rehabilitation in this population.
OBJECTIVE: To determine if APOE genotype is linked to memory function after moderate-severe traumatic brain injury (TBI). METHODS: Eighty-two patients in post-traumatic amnesia (PTA) and 107 patients who had emerged from PTA were selected from 239 consecutive patients admitted to the facility. Verbal memory assessments, including the Spanish version of the California Verbal Learning Test and the Working-Memory Index of the WAIS-III, were conducted immediately after PTA resolution or during the first week after admission for patients who were out of PTA. Both groups were reassessed 6 months after inclusion in a multidisciplinary rehabilitation programme. RESULTS:Patients with the APOE-epsilon 4 allele (n = 17 in the PTA group and n = 9 in the out of PTA group) entered rehabilitation at a more impaired level, but made remarkable progress during follow-up. Fifty-five patients from the initial sample emerged from PTA during the follow-up period. Age, GOAT at admission and chronicity, but not APOE genotype or initial trauma severity, were significant predictors of emergence from PTA. CONCLUSIONS:APOE genotype seems to be associated with the trajectory of cognitive recovery after TBI, but does not play a determinant role in the efficacy of memory rehabilitation in this population.
Authors: Raquel C Gardner; Jing Cheng; Adam R Ferguson; Ross Boylan; John Boscardin; Ross D Zafonte; Geoffrey T Manley Journal: J Neurotrauma Date: 2019-05-24 Impact factor: 5.269
Authors: John K Yue; Caitlin K Robinson; John F Burke; Ethan A Winkler; Hansen Deng; Maryse C Cnossen; Hester F Lingsma; Adam R Ferguson; Thomas W McAllister; Jonathan Rosand; Esteban G Burchard; Marco D Sorani; Sourabh Sharma; Jessica L Nielson; Gabriela G Satris; Jason F Talbott; Phiroz E Tarapore; Frederick K Korley; Kevin K W Wang; Esther L Yuh; Pratik Mukherjee; Ramon Diaz-Arrastia; Alex B Valadka; David O Okonkwo; Geoffrey T Manley Journal: Brain Behav Date: 2017-08-09 Impact factor: 2.708
Authors: Charles A McFadyen; Frederick A Zeiler; Virginia Newcombe; Anneliese Synnot; Ewout Steyerberg; Russel L Gruen; Jonathan Rosand; Aarno Palotie; Andrew I R Maas; David K Menon Journal: J Neurotrauma Date: 2019-09-17 Impact factor: 5.269