INTRODUCTION: Vulvar cancer is a rare condition representing about 4% of all female genital tract tumors. In contrast to the established relationship of virtually all cervical cancer cases with the human papillomavirus (HPV) infection, the reported HPV positivity in vulvar carcinoma ranges widely. METHODS: Using the Linear Array HPV Genotyping Test, we investigated the HPV incidence in a group of 46 Polish patients with vulvar squamous cell carcinoma (age range, 37-93 years; median age, 70.2 years) in clinical stages T1-2, N0-2, and M0. RESULTS: The presence of HPV DNA was confirmed in 7 of 46 (15%) primary tumor samples. HPV 16 was found in 5 tumors (71%). HPVs 6 and 58 were detected in the remaining 2 cases of virus-associated tumors. CONCLUSIONS: We conclude that a fraction of cancers of vulva associated with HPV is insignificant, given the HPV prevalence of 8.6% in the Polish population aged 55 to 59 years (the oldest cohort of Polish women studied to date).
INTRODUCTION:Vulvar cancer is a rare condition representing about 4% of all female genital tract tumors. In contrast to the established relationship of virtually all cervical cancer cases with the human papillomavirus (HPV) infection, the reported HPV positivity in vulvar carcinoma ranges widely. METHODS: Using the Linear Array HPV Genotyping Test, we investigated the HPV incidence in a group of 46 Polish patients with vulvar squamous cell carcinoma (age range, 37-93 years; median age, 70.2 years) in clinical stages T1-2, N0-2, and M0. RESULTS: The presence of HPV DNA was confirmed in 7 of 46 (15%) primary tumor samples. HPV 16 was found in 5 tumors (71%). HPVs 6 and 58 were detected in the remaining 2 cases of virus-associated tumors. CONCLUSIONS: We conclude that a fraction of cancers of vulva associated with HPV is insignificant, given the HPV prevalence of 8.6% in the Polish population aged 55 to 59 years (the oldest cohort of Polish women studied to date).
Authors: Aleksandra Klemba; Magdalena Kowalewska; Wojciech Kukwa; Katarzyna Tonska; Aleksandra Szybinska; Malgorzata Mossakowska; Anna Scinska; Paweł Golik; Kamil Koper; Jakub Radziszewski; Andrzej Kukwa; Anna M Czarnecka; Ewa Bartnik Journal: J Biomed Sci Date: 2010-09-08 Impact factor: 8.410
Authors: Magdalena Kowalewska; Jakub Radziszewski; Krzysztof Goryca; Mateusz Bujko; Malgorzata Oczko-Wojciechowska; Michal Jarzab; Janusz Aleksander Siedlecki; Mariusz Bidzinski Journal: BMC Cancer Date: 2012-06-06 Impact factor: 4.430
Authors: Ruth Tachezy; Jana Smahelova; Martina Salakova; Marc Arbyn; Lukas Rob; Petr Skapa; Tomas Jirasek; Eva Hamsikova Journal: PLoS One Date: 2011-07-13 Impact factor: 3.240