PURPOSE: To investigate the levels of antioxidant enzymes catalase (CAT), glutathione peroxidase (GPO), superoxide dismutase (SOD), and malondialdehyde (MDA) in human eyes with primary open-angle glaucoma (POAG) and to correlate their concentrations with severity of glaucoma. DESIGN: A prospective cases control study. PATIENTS AND METHODS: Thirty patients with primary open-angle glaucoma and twenty-five patients with senile cataracts of matched age and gender were included in the study prospectively. Aqueous humor samples were obtained by paracentesis at the time of elective surgery for glaucomatous and cataractous patients. Aqueous humor were analyzed for CAT, GPO, SOD, and MDA status. RESULTS: GPO, SOD, and MDA enzyme levels revealed a high significant increase in aqueous humor of POAG patients with respect to the comparative group of cataract patients (P < 0.001). No significant difference in the activity of CAT enzyme in aqueous humor of POAG and cataract patient (P = 0.201). Significant correlation was found between the MDA enzyme level and severe visual field loss (P < 0.001) in POAG patients. CONCLUSION: Increased levels of aqueous humor GPO, SOD, and MDA may be associated with POAG. In addition, they may be useful antioxidant enzyme levels in aqueous humor of POAG patients as a result of glaucoma disease and not a cause.
PURPOSE: To investigate the levels of antioxidant enzymes catalase (CAT), glutathione peroxidase (GPO), superoxide dismutase (SOD), and malondialdehyde (MDA) in human eyes with primary open-angle glaucoma (POAG) and to correlate their concentrations with severity of glaucoma. DESIGN: A prospective cases control study. PATIENTS AND METHODS: Thirty patients with primary open-angle glaucoma and twenty-five patients with senile cataracts of matched age and gender were included in the study prospectively. Aqueous humor samples were obtained by paracentesis at the time of elective surgery for glaucomatous and cataractouspatients. Aqueous humor were analyzed for CAT, GPO, SOD, and MDA status. RESULTS: GPO, SOD, and MDA enzyme levels revealed a high significant increase in aqueous humor of POAG patients with respect to the comparative group of cataractpatients (P < 0.001). No significant difference in the activity of CAT enzyme in aqueous humor of POAG and cataractpatient (P = 0.201). Significant correlation was found between the MDA enzyme level and severe visual field loss (P < 0.001) in POAG patients. CONCLUSION: Increased levels of aqueous humor GPO, SOD, and MDA may be associated with POAG. In addition, they may be useful antioxidant enzyme levels in aqueous humor of POAG patients as a result of glaucoma disease and not a cause.
Authors: Gözde Hondur; Emre Göktas; Xiangjun Yang; Lama Al-Aswad; James D Auran; Dana M Blumberg; George A Cioffi; Jeffrey M Liebmann; Leejee H Suh; Danielle Trief; Gülgün Tezel Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799
Authors: Susan D Orwig; Christopher W Perry; Laura Y Kim; Katherine C Turnage; Rong Zhang; Douglas Vollrath; Ingeborg Schmidt-Krey; Raquel L Lieberman Journal: J Mol Biol Date: 2011-12-13 Impact factor: 5.469
Authors: Kristin S Biggerstaff; Donna L White; Benjamin J Frankfort; Peter Richardson; Silvia Orengo-Nania; Jose Garcia; Elizabeth Y Chiao; Jennifer R Kramer Journal: Graefes Arch Clin Exp Ophthalmol Date: 2021-07-17 Impact factor: 3.117
Authors: Wesley S Bond; Jessica Hines-Beard; YPaul L GoldenMerry; Mara Davis; Alma Farooque; Rebecca M Sappington; David J Calkins; Tonia S Rex Journal: Mol Ther Date: 2015-10-27 Impact factor: 11.454