Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons.

CE is the extract from Coeloglossum viride var.bracteatum, a plant widely used as a traditional medicine in the Southwest China, such as Tibet. The effects of CE against amyloid toxicity in cell culture were examined in the present study. The results indicate that CE can protect against amyloid beta (Abeta)(25-35)-induced cytotoxicity in rat primary prefrontal cortex neurons. Bcl(2) and Csp3 activation may be involved in CE protection. CE could be a promising candidate for amyloid-based Alzheimer's disease (AD) prevention or therapy.