Literature DB >> 20368180

Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification.

John P A Ioannidis1, En Yun Loy, Richie Poulton, Kee Seng Chia.   

Abstract

Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.

Mesh：

Year:  2009        PMID： 20368180     DOI： 10.1126/scitranslmed.3000247

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  41 in total

Review 1.  A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

Authors:  John P A Ioannidis; Peter Castaldi; Evangelos Evangelou
Journal:  J Natl Cancer Inst       Date:  2010-05-26       Impact factor: 13.506

Review 2.  Epidemiology research in rheumatology-progress and pitfalls.

Authors:  Deborah P M Symmons
Journal:  Nat Rev Rheumatol       Date:  2015-07-07       Impact factor: 20.543

3.  Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans.

Authors:  Paolo Boffetta; Deborah M Winn; John P Ioannidis; Duncan C Thomas; Julian Little; George Davey Smith; Vincent J Cogliano; Stephen S Hecht; Daniela Seminara; Paolo Vineis; Muin J Khoury
Journal:  Int J Epidemiol       Date:  2012-05-16       Impact factor: 7.196

Review 4.  Cancer evolution and individual susceptibility.

Authors:  Jesús Pérez-Losada; Andrés Castellanos-Martín; Jian-Hua Mao
Journal:  Integr Biol (Camb)       Date:  2011-01-24       Impact factor: 2.192

5.  Medicine. Big data meets public health.

Authors:  Muin J Khoury; John P A Ioannidis
Journal:  Science       Date:  2014-11-28       Impact factor: 47.728

6.  The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments.

Authors:  Sinan Guloksuz; Bart P F Rutten; Lotta-Katrin Pries; Margreet Ten Have; Ron de Graaf; Saskia van Dorsselaer; Boris Klingenberg; Jim van Os; John P A Ioannidis
Journal:  Schizophr Bull       Date:  2018-10-17       Impact factor: 9.306

Review 7.  Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health.

Authors:  Arjun K Manrai; Yuxia Cui; Pierre R Bushel; Molly Hall; Spyros Karakitsios; Carolyn J Mattingly; Marylyn Ritchie; Charles Schmitt; Denis A Sarigiannis; Duncan C Thomas; David Wishart; David M Balshaw; Chirag J Patel
Journal:  Annu Rev Public Health       Date:  2016-12-23       Impact factor: 21.981

8.  Perspective: Limiting Dependence on Nonrandomized Studies and Improving Randomized Trials in Human Nutrition Research: Why and How.

Authors:  John F Trepanowski; John P A Ioannidis
Journal:  Adv Nutr       Date:  2018-07-01       Impact factor: 8.701

9.  A nutrient-wide association study on blood pressure.

Authors:  Ioanna Tzoulaki; Chirag J Patel; Tomonori Okamura; Queenie Chan; Ian J Brown; Katsuyuki Miura; Hirotsugu Ueshima; Liancheng Zhao; Linda Van Horn; Martha L Daviglus; Jeremiah Stamler; Atul J Butte; John P A Ioannidis; Paul Elliott
Journal:  Circulation       Date:  2012-10-23       Impact factor: 29.690

10.  An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus.

Authors:  Chirag J Patel; Jayanta Bhattacharya; Atul J Butte
Journal:  PLoS One       Date:  2010-05-20       Impact factor: 3.240
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