Literature DB >> 20362442

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.

Chavi Yenjai1, Suchana Wanich.   

Abstract

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20362442     DOI： 10.1016/j.bmcl.2010.03.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

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Journal:  Tetrahedron       Date:  2013-02-04       Impact factor: 2.457

3.  Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome.

Authors:  Kazuya Murata; Hirotaka Hayashi; Shinichi Matsumura; Hideaki Matsuda
Journal:  Pharmacognosy Res       Date:  2013-10

4.  Synthesis and Biological Activity of Novel O-Alkyl Derivatives of Naringenin and Their Oximes.

Authors:  Joanna Kozłowska; Bartłomiej Potaniec; Barbara Żarowska; Mirosław Anioł
Journal:  Molecules       Date:  2017-09-06       Impact factor: 4.411

5.  Structural modification of olibergin A, an isoflavonoid, from Dalbergia stipulacea Roxb. and its cytotoxicity.

Authors:  Supakorn Arthan; Priyapan Posri; Sookkawath Walunchapruk; Thanaset Senawong; Chavi Yenjai
Journal:  RSC Adv       Date:  2022-06-16       Impact factor: 4.036
  5 in total

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