Literature DB >> 20360746

Abscission accomplished by PtdIns(3)P.

Guillaume Montagnac1, Philippe Chavrier.   

Abstract

Cytokinesis - the final step of mitosis in which the two daughter cells separate - requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.

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Year:  2010        PMID： 20360746     DOI： 10.1038/ncb0410-308

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  18 in total

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5.  PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

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