| Literature DB >> 19852987 |
Marco Falasca1, Tania Maffucci.
Abstract
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years.Entities:
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Year: 2009 PMID： 19852987 DOI： 10.1016/j.bbamcr.2009.10.003
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002