Literature DB >> 20358097

A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.

Christophe Corre1, Stuart W Haynes, Nicolas Malet, Lijiang Song, Gregory L Challis.   

Abstract

The label from [3-(13)C]-L-glycerol is incorporated into the hydroxymethyl group of methylenomycin furans suggesting a butenolide intermediate in their biosynthesis.

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Year:  2010        PMID： 20358097     DOI： 10.1039/c000496k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.

Authors:  Gregory L Challis
Journal:  J Ind Microbiol Biotechnol       Date:  2013-12-10       Impact factor: 3.346

2.  Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones.

Authors:  Iti Kapoor; Philip Olivares; Satish K Nair
Journal:  Elife       Date:  2020-06-08       Impact factor: 8.140

3.  Signalling and Bioactive Metabolites from Streptomyces sp. RK44.

Authors:  Qing Fang; Fleurdeliz Maglangit; Linrui Wu; Rainer Ebel; Kwaku Kyeremeh; Jeanette H Andersen; Frederick Annang; Guiomar Pérez-Moreno; Fernando Reyes; Hai Deng
Journal:  Molecules       Date:  2020-01-22       Impact factor: 4.411

4.  Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.

Authors:  Ioanna T Nakou; Matthew Jenner; Yousef Dashti; Isolda Romero-Canelón; Joleen Masschelein; Eshwar Mahenthiralingam; Gregory L Challis
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-26       Impact factor: 15.336
  4 in total

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