INTRODUCTION: Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IA patients from one UK region who received overseas transplants with IA patients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis. METHODS: Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IA patients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group. RESULTS: In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001). CONCLUSION: IA patients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly.
INTRODUCTION: Some Indoasian (IA) patients with established renal failure travel abroad for commercial kidney transplantation. We compared the 1-year outcomes of IApatients from one UK region who received overseas transplants with IApatients receiving local living donor (LD) kidney transplantation, deceased donor (DD) transplantation, and dialysis. METHODS: Between 1996 and 2006, 40 adults were transplanted overseas; 38 were IA, and follow-up data were available on 36 patients. Forty IApatients received LD transplants, and 156 patients received DD transplants locally. A cohort of 120 prospective dialysis patients was also used as a comparator group. RESULTS: In the overseas cohort, 20 patients (56%) were not active in the UK transplant waiting list at the time of kidney transplantation overseas. One-year graft survival was 87%, and 1-year patient survival was 83%. Composite graft and patient survival was 69.5% at 1 year. In the local LD transplant recipients, patient survival was 97.5% (39 of 40; P=0.03), and graft survival was 97.5% (39 of 40; P=0.06). Composite graft and patient survival was 95% (P=0.003). In the overseas group, 42% had major infections compared with 15% in the local group (P=0.02). One-year graft survival for DD transplant was 84.6% (132 of 156), and 1-year patient survival was 93% (145 of 156; P=NS and P=0.06, respectively). In the dialysis group, 1-year patient survival was 96.7% (116 of 120; P=0.001). CONCLUSION:IApatients who choose to travel overseas for kidney transplantation have poor clinical outcomes and should be counseled accordingly.
Authors: Arthur J Matas; Sally Satel; Stephen Munn; Janet Radcliffe Richards; Angeles Tan-Alora; Frederike J A E Ambagtsheer; Micheal D H Asis; Leo Baloloy; Edward Cole; Jeff Crippin; David Cronin; Abdallah S Daar; James Eason; Richard Fine; Sander Florman; Richard Freeman; John Fung; Wulf Gaertner; Robert Gaston; Nasrollah Ghahramani; Ahad Ghods; Michelle Goodwin; Thomas Gutmann; Nadey Hakim; Benjamin Hippen; Ajit Huilgol; Igal Kam; Arlene Lamban; Walter Land; Alan Langnas; Reynaldo Lesaca; Gary Levy; RoseMarie Liquette; William H Marks; Charles Miller; Enrique Ona; Glenda Pamugas; Antonio Paraiso; Thomas G Peters; David Price; Gurch Randhawa; Alan Reed; Keith Rigg; Dennis Serrano; Hans Sollinger; Sankaran Sundar; Lewis Teperman; Gert van Dijk; Willem Weimar; Romina Danguilan Journal: Am J Transplant Date: 2011-12-17 Impact factor: 8.086