Literature DB >> 203544

Induction of EBNA precedes the first cellular S-phase after EBV-infection of human lymphocytes.

L Einhorn, I Ernberg.   

Abstract

Using a combination of immunofluorescence and autoradiography, we studied the appearance of EBNA and DNA synthesis in cord-blood lymphocytes after infection with EBV derived from the B95-8 cell line. EBNA appeared between 12 and 25 h after addition of the virus. DNA synthesis was detected in EBNA-positive cells approximately 20 h after the appearance of EBNA. This shows that EBNA induction precedes the first cellular S-phase and suggests that the cells have not yet entered the cell-division cycle when EBNA appears. Little, if any, of the total DNA synthesis induced at this stage can be attributed to EBV-mediated immunologic stimulation.

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Year:  1978        PMID： 203544     DOI： 10.1002/ijc.2910210205

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  17 in total

1.  Induction of Epstein-Barr virus nuclear antigens.

Authors:  D J Moss; T B Sculley; J H Pope
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

2.  Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells.

Authors:  K P Mann; D Staunton; D A Thorley-Lawson
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

3.  A routine method for the establishment of permanent growing lymphoblastoid cell lines.

Authors:  H Neitzel
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132

4.  The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and Ig gene rearrangement.

Authors:  J V Melo; L Foroni; V Brito-Babapulle; L Luzzatto; D Catovsky
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330

Review 5.  Cell-mediated immunity against Epstein-Barr virus infected B lymphocytes.

Authors:  E Klein; M G Masucci
Journal:  Springer Semin Immunopathol       Date:  1982

Review 6.  Epstein-Barr virus (EBV), lymphocytes and transformation.

Authors:  J Zeuthen
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

7.  Enhancive and suppressive effects of cytomegalovirus on human lymphocyte responses in vitro.

Authors:  B Wahren; P Ljungman; T Paulin; O Ringdén
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

8.  Interaction of Epstein-Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells.

Authors:  A B Rickinson; S Finerty; M A Epstein
Journal:  Clin Exp Immunol       Date:  1982-11       Impact factor: 4.330

9.  Induction of Epstein-Barr virus nuclear antigen and DNA synthesis in a human epithelial cell line after Epstein-Barr virus infection.

Authors:  H Ben-Bassat; S Mitrani-Rosenbaum; N Goldblum
Journal:  J Virol       Date:  1982-02       Impact factor: 5.103

10.  Dimer-size DNA circles in a leukemic cell immortalized with the Epstein-Barr virus.

Authors:  E Gussander; A Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205
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