| Literature DB >> 20353885 |
Ying Xu1, Zhichao Wang, Wenting You, Xiuhua Zhang, Shan Li, Philip A Barish, Matthew M Vernon, Xia Du, Gaowen Li, Jianchun Pan, William O Ogle.
Abstract
The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation. Published by Elsevier B.V.Entities:
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Year: 2010 PMID： 20353885 DOI： 10.1016/j.euroneuro.2010.02.013
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600