Literature DB >> 20352077

Stable-isotope dilution LC–MS for quantitative biomarker analysis.

Eugene Ciccimaro1, Ian A Blair.   

Abstract

The ability to conduct validated analyses of biomarkers is critically important in order to establish the sensitivity and selectivity of the biomarker in identifying a particular disease. The use of stable-isotope dilution (SID) methodology in combination with LC–MS/MS provides the highest possible analytical specificity for quantitative determinations. This methodology is now widely used in the discovery and validation of putative exposure and disease biomarkers. This review will describe the application of SID LC–MS methodology for the analysis of small-molecule and protein biomarkers. It will also discuss potential future directions for the use of this methodology for rigorous biomarker analysis.

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Year:  2010        PMID： 20352077      PMCID： PMC2843934          DOI： 10.4155/bio.09.185

Source DB:  PubMed          Journal:  Bioanalysis        ISSN： 1757-6180            Impact factor:   2.681


  247 in total

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2.  DNA and protein adducts as markers of genotoxicity.

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4.  Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.

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Review 5.  A human proteome detection and quantitation project.

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7.  Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance.

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9.  Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery.

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Review 10.  Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?

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  60 in total

1.  Relative quantification of serum proteins from pancreatic ductal adenocarcinoma patients by stable isotope dilution liquid chromatography-mass spectrometry.

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Authors:  Ding Lu; Ronald G Harvey; Ian A Blair; Trevor M Penning
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3.  Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets.

Authors:  Andrew J Worth; Sankha S Basu; Eric C Deutsch; Wei-Ting Hwang; Nathaniel W Snyder; David R Lynch; Ian A Blair
Journal:  Bioanalysis       Date:  2015       Impact factor: 2.681

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5.  8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress.

Authors:  Clementina Mesaros; Jasbir S Arora; Ashley Wholer; Anil Vachani; Ian A Blair
Journal:  Free Radic Biol Med       Date:  2012-05-18       Impact factor: 7.376

Review 6.  Mass spectrometry strategies for clinical metabolomics and lipidomics in psychiatry, neurology, and neuro-oncology.

Authors:  Paul L Wood
Journal:  Neuropsychopharmacology       Date:  2013-07-11       Impact factor: 7.853

7.  PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.

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Journal:  Nat Med       Date:  2013-08-18       Impact factor: 53.440

8.  Proteomic Interrogation in Cancer Biomarker.

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9.  Reverse-polynomial dilution calibration methodology extends lower limit of quantification and reduces relative residual error in targeted peptide measurements in blood plasma.

Authors:  Yunki Y Yau; Xizi Duo; Rupert W L Leong; Valerie C Wasinger
Journal:  Mol Cell Proteomics       Date:  2014-12-09       Impact factor: 5.911

10.  Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS.

Authors:  Sankha S Basu; Eric C Deutsch; Alec A Schmaier; David R Lynch; Ian A Blair
Journal:  Bioanalysis       Date:  2013-12       Impact factor: 2.681
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