OBJECTIVE: Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. METHODS: Serum levels of lipids, lipoprotein, triglyceride-rich lipoproteins (TRLs), and high-density lipoprotein (HDL) particles were determined, lipid and lipoprotein ratios were calculated, and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Tx patients had disturbed concentration, composition, and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios, which indicates that both ratios could sensitively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients, the decreased HDL-C/apoAI ratio indicates that, along with the decreased apoAI concentration, the HDL-C level is decreased. However, a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio), and thus are hypercatabolized and removed; therefore, concentration of HDL particles in serum was decreased. CONCLUSION: The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles.
OBJECTIVE: Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. METHODS: Serum levels of lipids, lipoprotein, triglyceride-rich lipoproteins (TRLs), and high-density lipoprotein (HDL) particles were determined, lipid and lipoprotein ratios were calculated, and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Tx patients had disturbed concentration, composition, and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios, which indicates that both ratios could sensitively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients, the decreased HDL-C/apoAI ratio indicates that, along with the decreased apoAI concentration, the HDL-C level is decreased. However, a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio), and thus are hypercatabolized and removed; therefore, concentration of HDL particles in serum was decreased. CONCLUSION: The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles.
Authors: Shirya Rashid; P Hugh R Barrett; Kristine D Uffelman; Takehiko Watanabe; Khosrow Adeli; Gary F Lewis Journal: Arterioscler Thromb Vasc Biol Date: 2002-03-01 Impact factor: 8.311
Authors: B Kasiske; F G Cosio; J Beto; K Bolton; B M Chavers; R Grimm; A Levin; B Masri; R Parekh; C Wanner; D C Wheeler; P W F Wilson Journal: Am J Transplant Date: 2004 Impact factor: 8.086
Authors: Elżbieta Kimak; Magdalena Hałabiś; Iwona Baranowicz-Gąszczyk; Janusz Solski; Andrzej Książek Journal: J Zhejiang Univ Sci B Date: 2011-05 Impact factor: 3.066
Authors: Elżbieta Kimak; Jerzy Bylina; Janusz Solski; Magdalena Hałabiś; Iwona Baranowicz-Gąszczyk; Andrzej Książek Journal: Cell Biochem Biophys Date: 2013-11 Impact factor: 2.194