| Literature DB >> 20347771 |
Daisuke Yasokawa1, Satomi Murata, Yumiko Iwahashi, Emiko Kitagawa, Katsuyuki Kishi, Yukihiro Okumura, Hitoshi Iwahashi.
Abstract
Zinc pyrithione has been used in anti-dandruff shampoos and in anti-fouling paint on ships. However, little is known of its mode of action. We characterized the effects of sub-lethal concentrations of zinc pyrithione (Zpt) on Saccharomyces cerevisiae using DNA microarrays. The majority of the strongly upregulated genes are related to iron transport, and many of the strongly downregulated genes are related to the biosynthesis of cytochrome (heme). These data suggest that Zpt induces severe iron starvation. To confirm the DNA microarray data, we supplemented cultures containing Zpt with iron, and the growth of the yeast was restored significantly. From these results, we propose that the principal toxicity of zinc pyrithione arises from iron starvation. (c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 20347771 DOI： 10.1016/j.jbiosc.2009.10.025
Source DB: PubMed Journal: J Biosci Bioeng ISSN： 1347-4421 Impact factor: 2.894