Literature DB >> 20347211

Neoadjuvant temsirolimus effectiveness in downstaging advanced non-clear cell renal cell carcinoma.

Oscar Rodríguez Faba1, Alberto Breda, Antonio Rosales, Joan Palou, Ferran Algaba, Pablo Maroto Rey, Humberto Villavicencio.   

Abstract

A 35-year-old woman presented with a 12-cm right renal mass with retroperitoneal lymph node involvement and pulmonary and bone metastases. Renal mass biopsy revealed an unclassified high-grade non-clear cell renal cell carcinoma (RCC) with eosinophilic cells. Due to the extent of the disease, neoadjuvant temsirolimus was initiated. After 6 wk of treatment, a significant downstaging of the disease and complete disappearance of the metastases were noticed on computed tomography scan. Three months later, a laparoscopic radical nephrectomy and lymphadenectomy was performed. Final pathology confirmed a high-grade non-clear cell RCC, with necrotic changes on lymph node specimens, pT1bN0Mx. Copyright (c) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 20347211     DOI: 10.1016/j.eururo.2010.03.005

Source DB:  PubMed          Journal:  Eur Urol        ISSN: 0302-2838            Impact factor:   20.096


  3 in total

Review 1.  Recommendations for the clinical and radiological evaluation of response to treatment in metastatic renal cell cancer.

Authors:  Luís León; Roberto García-Figueiras; Roberto García-Figueras; Cristina Suárez; Antonia Arjonilla; Javier Puente; Blanca Vargas; Maria José Méndez Vidal; Carmen Sebastiá
Journal:  Target Oncol       Date:  2013-12-12       Impact factor: 4.493

Review 2.  Prognostic Benefit of Surgical Management of Renal Cell Carcinoma Invading the Inferior Vena Cava.

Authors:  Aikaterini Mastoraki; Sotiria Mastoraki; Maria Tsikala-Vafea; Ioannis S Papanikolaou; Andreas Lazaris; Vassilios Smyrniotis; Nikolaos Arkadopoulos
Journal:  Indian J Surg Oncol       Date:  2016-05-04

3.  Small (<4 cm), Unclassified Renal Cell Carcinoma Presenting with Initial Bone Metastasis: A Case of a Metastatic Lesion Missed at the Initial Diagnosis.

Authors:  Seung Je Lee; Eu Chang Hwang; In Sang Hwang; Ho Song Yu; Sun-Ouck Kim; Seung Il Jung; Taek Won Kang; Dong Deuk Kwon; Hyun-Jeong Shim; Chan Choi
Journal:  Korean J Urol       Date:  2012-12-20
  3 in total

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