Literature DB >> 20346655

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Steve D Fidanze1, Scott A Erickson, Gary T Wang, Robert Mantei, Richard F Clark, Bryan K Sorensen, Nwe Y Bamaung, Peter Kovar, Eric F Johnson, Kerren K Swinger, Kent D Stewart, Qian Zhang, Lora A Tucker, William N Pappano, Julie L Wilsbacher, Jieyi Wang, George S Sheppard, Randy L Bell, Steven K Davidsen, Robert D Hubbard.   

Abstract

The design and enzyme activities of a novel class of imidazo[2,1-b]thiazoles is presented. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20346655     DOI： 10.1016/j.bmcl.2010.03.015

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

Review 1.  In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.

Authors:  C I Wells; N R Kapadia; R M Couñago; D H Drewry
Journal:  Medchemcomm       Date:  2017-12-08       Impact factor: 3.597

2.  Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?

Authors:  Brett M Collins; Melissa J Davis; John F Hancock; Robert G Parton
Journal:  Dev Cell       Date:  2012-07-17       Impact factor: 12.270

3.  Statistical analysis of EGFR structures' performance in virtual screening.

Authors:  Yan Li; Xiang Li; Zigang Dong
Journal:  J Comput Aided Mol Des       Date:  2015-10-17       Impact factor: 3.686

Review 4.  Regulation of the catalytic activity of the EGF receptor.

Authors:  Nicholas F Endres; Kate Engel; Rahul Das; Erika Kovacs; John Kuriyan
Journal:  Curr Opin Struct Biol       Date:  2011-08-23       Impact factor: 6.809

5.  Identification of potent EGFR inhibitors from TCM Database@Taiwan.

Authors:  Shun-Chieh Yang; Su-Sen Chang; Hsin-Yi Chen; Calvin Yu-Chian Chen
Journal:  PLoS Comput Biol       Date:  2011-10-13       Impact factor: 4.475

Review 6.  Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives.

Authors:  Meizhong Jin; Elizabeth Buck; Mark J Mulvihill
Journal:  Oncol Rev       Date:  2013-04-22

7.  Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives.

Authors:  Huaiwei Ding; Zhe Chen; Cunlong Zhang; Tian Xin; Yini Wang; Hongrui Song; Yuyang Jiang; Yuzong Chen; Yongnan Xu; Chunyan Tan
Journal:  Molecules       Date:  2012-04-23       Impact factor: 4.411

8.  Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent.

Authors:  Wei Liu; Jin-Feng Ning; Qing-Wei Meng; Jing Hu; Yan-Bin Zhao; Chao Liu; Li Cai
Journal:  Drug Des Devel Ther       Date:  2015-07-23       Impact factor: 4.162

9.  QSAR-based models for designing quinazoline/imidazothiazoles/pyrazolopyrimidines based inhibitors against wild and mutant EGFR.

Authors:  Jagat Singh Chauhan; Sandeep Kumar Dhanda; Deepak Singla; Subhash M Agarwal; Gajendra P S Raghava
Journal:  PLoS One       Date:  2014-07-03       Impact factor: 3.240

10.  Rational design of non-resistant targeted cancer therapies.

Authors:  Francisco Martínez-Jiménez; John P Overington; Bissan Al-Lazikani; Marc A Marti-Renom
Journal:  Sci Rep       Date:  2017-04-24       Impact factor: 4.379
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