Literature DB >> 20345320

Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient.

Ferhat Arslan1, Fehmi Tabak, Emin Avşar, Kenan Midilli, Ali Mert, Resat Ozaras, Teoman Soysal, Recep Ozturk, Burhan Ferhanoglu.   

Abstract

We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and blood showed CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. Foscarnet resistance mutations were not found. Although therapy was switched to foscarnet when ganciclovir resistance was suspected, the patient was lost on posttransplant day 200.

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Year:  2010        PMID： 20345320     DOI： 10.3109/13550281003682539

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  16 in total

1.  Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.

Authors:  S K Seo; A Regan; T Cihlar; D C Lin; F Boulad; D George; V K Prasad; T E Kiehn; B Polsky
Journal:  Clin Infect Dis       Date:  2001-09-26       Impact factor: 9.079

2.  Acyclovir for prevention of cytomegalovirus infection and disease after allogeneic marrow transplantation.

Authors:  J D Meyers; E C Reed; D H Shepp; M Thornquist; P S Dandliker; C A Vicary; N Flournoy; L E Kirk; J H Kersey; E D Thomas
Journal:  N Engl J Med       Date:  1988-01-14       Impact factor: 91.245

3.  A risk-adapted approach with a short course of ganciclovir to prevent cytomegalovirus (CMV) pneumonia in CMV-seropositive recipients of allogeneic bone marrow transplants.

Authors:  L F Verdonck; A W Dekker; M Rozenberg-Arska; M R van den Hoek
Journal:  Clin Infect Dis       Date:  1997-05       Impact factor: 9.079

4.  Cytomegalovirus ventriculoencephalitis in a peripheral blood stem cell transplant recipient.

Authors:  Geraldine G Miller; Guy Boivin; J Stephen Dummer; Thomas McConnell; Mark W Becher; Adetola Kassim; Yi-Wei Tang
Journal:  Clin Infect Dis       Date:  2006-01-06       Impact factor: 9.079

5.  Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.

Authors:  J E Julin; J H van Burik; W Krivit; C Webb; C J Holman; H B Clark; H H Balfour
Journal:  Transpl Infect Dis       Date:  2002-12       Impact factor: 2.228

Review 6.  Cytomegalovirus encephalitis.

Authors:  J R Arribas; G A Storch; D B Clifford; A C Tselis
Journal:  Ann Intern Med       Date:  1996-10-01       Impact factor: 25.391

7.  The development of cytomegalovirus encephalitis in AIDS patients receiving ganciclovir.

Authors:  S M Berman; R C Kim
Journal:  Am J Med       Date:  1994-05       Impact factor: 4.965

8.  Cytomegalovirus encephalitis in acquired immunodeficiency syndrome (AIDS).

Authors:  N R Holland; C Power; V P Mathews; J D Glass; M Forman; J C McArthur
Journal:  Neurology       Date:  1994-03       Impact factor: 9.910

9.  Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients.

Authors:  Dana G Wolf; Nell S Lurain; Tsila Zuckerman; Ron Hoffman; Judith Satinger; Alik Honigman; Niveen Saleh; Emanuel S Robert; Jacob M Rowe; Zipora Kra-Oz
Journal:  Blood       Date:  2002-08-22       Impact factor: 22.113

10.  Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain.

Authors:  Klaus Hamprecht; Tobias Eckle; Lothar Prix; Christoph Faul; Hermann Einsele; Gerhard Jahn
Journal:  J Infect Dis       Date:  2002-12-13       Impact factor: 5.226
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  2 in total

Review 1.  Opportunistic infections of the central nervous system in the transplant patient.

Authors:  Bruce A Cohen; Valentina Stosor
Journal:  Curr Neurol Neurosci Rep       Date:  2013-09       Impact factor: 5.081

Review 2.  Infectious encephalitis: Management without etiological diagnosis 48hours after onset.

Authors:  P Fillatre; Y Crabol; P Morand; L Piroth; J Honnorat; J P Stahl; M Lecuit
Journal:  Med Mal Infect       Date:  2017-03-15       Impact factor: 2.152
  2 in total

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