Literature DB >> 2033674

Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.

M I Nerenberg1, T Minor, J Price, D N Ernst, T Shinohara, H Schwarz.   

Abstract

Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.

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Year:  1991        PMID： 2033674      PMCID： PMC240995     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  HTLV-I associated myelopathy, a new clinical entity.

Authors:  M Osame; K Usuku; S Izumo; N Ijichi; H Amitani; A Igata; M Matsumoto; M Tara
Journal:  Lancet       Date:  1986-05-03       Impact factor: 79.321

2.  HTLV-I and tropical spastic paraparesis.

Authors:  C Bartholomew; F Cleghorn; W Charles; P Ratan; L Roberts; K Maharaj; N Jankey; H Daisley; B Hanchard; W Blattner
Journal:  Lancet       Date:  1986-07-12       Impact factor: 79.321

Review 3.  Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.

Authors:  A F Williams; J Gagnon
Journal:  Science       Date:  1982-05-14       Impact factor: 47.728

4.  Mouse nervous tissue iso-antigens.

Authors:  A E Reif; J M Allen
Journal:  Nature       Date:  1966-01-29       Impact factor: 49.962

5.  Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan.

Authors:  V S Kalyanaraman; M G Sarngadharan; Y Nakao; Y Ito; T Aoki; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Authors:  M Yoshida; I Miyoshi; Y Hinuma
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

7.  Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells.

Authors:  M Osame; M Matsumoto; K Usuku; S Izumo; N Ijichi; H Amitani; M Tara; A Igata
Journal:  Ann Neurol       Date:  1987-02       Impact factor: 10.422

8.  Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis.

Authors:  C A Mora; R M Garruto; P Brown; D Guiroy; O S Morgan; P Rodgers-Johnson; M Ceroni; R Yanagihara; L G Goldfarb; C J Gibbs
Journal:  Ann Neurol       Date:  1988       Impact factor: 10.422

9.  Degeneration of oxidative muscle fibers in HTLV-1 tax transgenic mice.

Authors:  M I Nerenberg; C A Wiley
Journal:  Am J Pathol       Date:  1989-12       Impact factor: 4.307

10.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205
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  9 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

2.  The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.

Authors:  T M Ross; S M Pettiford; P L Green
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

3.  In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein.

Authors:  M A Matthews; R B Markowitz; W S Dynan
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

4.  A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene.

Authors:  G Matthijs; P Marynen
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

5.  Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region.

Authors:  X Xu; D A Brown; I Kitajima; J Bilakovics; L W Fey; M I Nerenberg
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

6.  Transactivation of human T-cell leukemia virus type 1 by herpes simplex virus type 1.

Authors:  S Israel; M Mendelovitz; A Honigman
Journal:  Virus Genes       Date:  1995-02       Impact factor: 2.332

7.  Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture.

Authors:  R Grassmann; S Berchtold; I Radant; M Alt; B Fleckenstein; J G Sodroski; W A Haseltine; U Ramstedt
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

8.  Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

Authors:  X Xu; S H Kang; O Heidenreich; M Okerholm; J J O'Shea; M I Nerenberg
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

9.  Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

Authors:  M G von Herrath; J Dockter; M Nerenberg; J E Gairin; M B Oldstone
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307
  9 in total

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