| Literature DB >> 20334912 |
Cecilia Prata1, Carole Grasso, Stefano Loizzo, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Laura Zambonin, Diana Fiorentini, Gabriele Hakim, Michael V Berridge, Laura Landi.
Abstract
The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.Entities:
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Year: 2010 PMID： 20334912 DOI： 10.1016/j.leukres.2010.02.032
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156