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Literature DB >> 32253741

The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.

Didem Tezgin¹, Charles Giardina¹, George A Perdrizet², Lawrence E Hightower³.

Abstract

We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of cellular caloristasis networks. The information on the changes in cellular energy metabolism stimulated by HBOT presented here provides new insights into the cellular energy state and mitochondrial environment in which sHSPs function. These data will be useful in forming testable hypotheses about the functions of translocated sHSPs in human mitochondria responding to stressors.

Entities: CellLine Chemical Species

Keywords: Caloristasis; Cytoprotection; Diabetic kidney disease; HBOT; Hyperbaric oxygen therapy; Mitochondria; Oxidative stress; Proteostasis; Small HSPs

Mesh：

Substances：
Oxygen

Year: 2020 PMID： 32253741 PMCID： PMC7332662 DOI： 10.1007/s12192-020-01100-5

Source DB: PubMed Journal: Cell Stress Chaperones ISSN： 1355-8145 Impact factor: 3.667

34 in total

The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.

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