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Literature DB >> 20334627

O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.

Shannon Weiman¹, Satoshi Uchiyama, Feng-Ying C Lin, Donald Chaffin, Ajit Varki, Victor Nizet, Amanda L Lewis.

Abstract

GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2010 PMID： 20334627 PMCID： PMC3640289 DOI： 10.1042/BJ20100232

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

45 in total

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