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Literature DB >> 12438406

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.

Abstract

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

Entities: Chemical Disease Species

Mesh：

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Year: 2002 PMID： 12438406 PMCID： PMC133073 DOI： 10.1128/IAI.70.12.7176-7178.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

8 in total

1. Effects of lysozyme on Bacillus cereus 569: rupture of chains of bacteria and enhancement of sensitivity to autolysins.

Authors: D Westmacott; H R Perkins
Journal: J Gen Microbiol Date: 1979-11

2. Enzymatic deacetylation of N-acetylglucosamine residues in peptidoglycan from Bacillus cereus cell walls.

Authors: Y Araki; S Fukuoka; S Oba; E Ito
Journal: Biochem Biophys Res Commun Date: 1971-11-05 Impact factor: 3.575

3. Possible role of a choline-containing teichoic acid in the maintenance of normal cell shape and physiology in Streptococcus oralis.

Authors: D S Horne; A Tomasz
Journal: J Bacteriol Date: 1993-03 Impact factor: 3.490

4. Analysis of peptidoglycan structure from vegetative cells of Bacillus subtilis 168 and role of PBP 5 in peptidoglycan maturation.

Authors: A Atrih; G Bacher; G Allmaier; M P Williamson; S J Foster
Journal: J Bacteriol Date: 1999-07 Impact factor: 3.490

5. The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.

Authors: W Vollmer; A Tomasz
Journal: J Biol Chem Date: 2000-07-07 Impact factor: 5.157

6. Cerebrospinal fluid lysozyme in bacterial and viral meningitis.

Authors: M Klockars; S Reitamo; T Weber; Y Kerttula
Journal: Acta Med Scand Date: 1978

7. Triggering of pneumococcal autolysis by lysozyme.

Authors: P Cottagnoud; A Tomasz
Journal: J Infect Dis Date: 1993-03 Impact factor: 5.226

8. The action of lysozyme on peptidoglycan with N-unsubstituted glucosamine residues. Isolation of glycan fragments and their susceptibility to lysozyme.

Authors: K Amano; H Hayashi; Y Araki; E Ito
Journal: Eur J Biochem Date: 1977-06-01

8 in total

51 in total

10. The extracytoplasmic function sigma factor SigV plays a key role in the original model of lysozyme resistance and virulence of Enterococcus faecalis.

Authors: André Le Jeune; Riccardo Torelli; Maurizio Sanguinetti; Jean-Christophe Giard; Axel Hartke; Yanick Auffray; Abdellah Benachour
Journal: PLoS One Date: 2010-03-11 Impact factor: 3.240

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.

1. Effects of lysozyme on Bacillus cereus 569: rupture of chains of bacteria and enhancement of sensitivity to autolysins.

2. Enzymatic deacetylation of N-acetylglucosamine residues in peptidoglycan from Bacillus cereus cell walls.

3. Possible role of a choline-containing teichoic acid in the maintenance of normal cell shape and physiology in Streptococcus oralis.

4. Analysis of peptidoglycan structure from vegetative cells of Bacillus subtilis 168 and role of PBP 5 in peptidoglycan maturation.

5. The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.

6. Cerebrospinal fluid lysozyme in bacterial and viral meningitis.

7. Triggering of pneumococcal autolysis by lysozyme.

8. The action of lysozyme on peptidoglycan with N-unsubstituted glucosamine residues. Isolation of glycan fragments and their susceptibility to lysozyme.

Review 1. Modifications to the peptidoglycan backbone help bacteria to establish infection.

2. Identification and characterization of a novel polysaccharide deacetylase C (PdaC) from Bacillus subtilis.

3. O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.

4. Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.

5. LambdaSa1 and LambdaSa2 prophage lysins of Streptococcus agalactiae.

Review 6. Envelope Structures of Gram-Positive Bacteria.

7. The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.

8. Study of lysozyme resistance in Rhodococcus equi.

9. Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori.

10. The extracytoplasmic function sigma factor SigV plays a key role in the original model of lysozyme resistance and virulence of Enterococcus faecalis.