BACKGROUND: Early-onset psychosis is a symptomatically nonspecific and heterogeneous entity composed of several diagnoses. This study examined the dimensional structure of symptoms and the temporal stability of this structure during a 6-month follow-up. METHOD: A principal component factor analysis of the Positive and Negative Syndrome Scale was conducted at baseline, 4 weeks, and 6 months in a sample of 99 first-episode psychotic patients (mean age = 15.5 years). RESULTS: The factor analysis produced a 5-dimension solution (Positive, Negative, Depression, Cognitive, Hostility) that explained 62.4% of the variance at baseline, 63.4% at 4 weeks, and 65.1% at 6 months. Negative dimension was the most consistent and stable over time and was predominant at baseline (23.9%) and at 4 weeks (25.7%). Depression was predominant at 6 months (31.1%). CONCLUSIONS: There is a stable 5-dimension structure of symptoms in early-onset psychosis with varying predominance of symptoms over time. Negative symptoms are a core feature of psychosis and are thus important diagnostic criteria. (c) 2010 Physicians Postgraduate Press, Inc.
BACKGROUND: Early-onset psychosis is a symptomatically nonspecific and heterogeneous entity composed of several diagnoses. This study examined the dimensional structure of symptoms and the temporal stability of this structure during a 6-month follow-up. METHOD: A principal component factor analysis of the Positive and Negative Syndrome Scale was conducted at baseline, 4 weeks, and 6 months in a sample of 99 first-episode psychoticpatients (mean age = 15.5 years). RESULTS: The factor analysis produced a 5-dimension solution (Positive, Negative, Depression, Cognitive, Hostility) that explained 62.4% of the variance at baseline, 63.4% at 4 weeks, and 65.1% at 6 months. Negative dimension was the most consistent and stable over time and was predominant at baseline (23.9%) and at 4 weeks (25.7%). Depression was predominant at 6 months (31.1%). CONCLUSIONS: There is a stable 5-dimension structure of symptoms in early-onset psychosis with varying predominance of symptoms over time. Negative symptoms are a core feature of psychosis and are thus important diagnostic criteria. (c) 2010 Physicians Postgraduate Press, Inc.
Authors: Ditte L Vernal; Sandeep Kapoor; Aseel Al-Jadiri; Eva M Sheridan; Yehonathan Borenstein; Charles Mormando; Lisa David; Sukhbir Singh; Andrew J Seidman; Maren Carbon; Miriam Gerstenberg; Ema Saito; John M Kane; Hans-Christoph Steinhausen; Christoph U Correll Journal: J Child Adolesc Psychopharmacol Date: 2015-09 Impact factor: 2.576
Authors: Johnny Downs; Harry Dean; Suzannah Lechler; Nicola Sears; Rashmi Patel; Hitesh Shetty; Matthew Hotopf; Tamsin Ford; Marinos Kyriakopoulos; Covadonga M Diaz-Caneja; Celso Arango; James H MacCabe; Richard D Hayes; Laura Pina-Camacho Journal: Schizophr Bull Date: 2019-01-01 Impact factor: 9.306
Authors: Lee Fu-I; Wagner de S Gurgel; Sheila C Caetano; Rodrigo Machado-Vieira; Yuan P Wang Journal: Braz J Psychiatry Date: 2019-09-26 Impact factor: 2.697
Authors: Chantelle J Giesbrecht; Norm O'Rourke; Olga Leonova; Verena Strehlau; Karine Paquet; Fidel Vila-Rodriguez; William J Panenka; G William MacEwan; Geoffrey N Smith; Allen E Thornton; William G Honer Journal: PLoS One Date: 2016-03-21 Impact factor: 3.240