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Literature DB >> 2033087

HIV-associated Kaposi's sarcoma: new developments in epidemiology and molecular pathology.

Abstract

New epidemiological data give evidence for an unknown etiological agent of Kaposi's sarcoma (KS). Experimental support is provided by research on cultivated KS cells. These results contradict a direct involvement of HIV-1 in the pathogenesis of KS. Research on cultivated KS cells confirmed the hypothesis that KS spindle cells originate from endothelial cells and gave new insight into the pathogenesis of tumor cell growth. KS spindle cells secrete an autocrine acting growth promoting activity. Nevertheless, they seem to depend on several growth factors like PDGF and IL-6 provided by surrounding endothelial cells and macrophages, respectively. The results support the hypothesis of a tumor relying on paracrine acting factors more than on autocrine acting factors.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 2033087 DOI： 10.1007/bf01625423

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

34 in total

1. Virus-like infectious agent (VLIA) is a novel pathogenic mycoplasma: Mycoplasma incognitus.

Authors: S C Lo; J W Shih; P B Newton; D M Wong; M M Hayes; J R Benish; D J Wear; R Y Wang
Journal: Am J Trop Med Hyg Date: 1989-11 Impact factor: 2.345

2. Kaposi's sarcoma in HIV-negative homosexual men.

Authors: A E Friedman-Kien; B R Saltzman; Y Z Cao; M S Nestor; M Mirabile; J J Li; T A Peterman
Journal: Lancet Date: 1990-01-20 Impact factor: 79.321

3. Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin.

Authors: D Little; J W Said; R J Siegel; M Fealy; M C Fishbein
Journal: J Pathol Date: 1986-06 Impact factor: 7.996

Review 1. Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.

Authors: Emily Cousins; John Nicholas
Journal: Recent Results Cancer Res Date: 2014

2. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells.

Authors: Steven Milligan; Mairi Robinson; Elizabeth O'Donnell; David J Blackbourn
Journal: J Virol Date: 2004-03 Impact factor: 5.103

2 in total

HIV-associated Kaposi's sarcoma: new developments in epidemiology and molecular pathology.

1. Virus-like infectious agent (VLIA) is a novel pathogenic mycoplasma: Mycoplasma incognitus.

2. Kaposi's sarcoma in HIV-negative homosexual men.

3. Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin.

Review 4. Myogenic cells in Kaposi's sarcoma: an ultrastructural study.

5. The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.

6. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients.

7. Depletion of PDGF from serum inhibits growth of AIDS-related and sporadic Kaposi's sarcoma cells in culture.

8. Invasive activity and chemotactic response to growth factors by Kaposi's sarcoma cells.

9. A novel virus-like infectious agent in patients with AIDS.

10. Hepatitis B virus DNA in Kaposi sarcoma.

Review 1. Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.

2. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells.